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小菌落阴性酵母中生长抑制与线粒体功能的关系。II. 中枢神经系统药物对致病性和非致病性念珠菌属的影响。

Relationship between growth inhibition and mitochondrial function in petite-negative yeasts. II. Effects of central nervous system drugs upon pathogenic and non-pathogenic Candida species.

作者信息

Marmiroli N, Tedeschi F, Sabatini M A, Truzzi G, Ferrari C, Puglisi P P

出版信息

Biol Cell. 1985;53(1):75-9. doi: 10.1111/j.1768-322x.1985.tb00354.x.

DOI:10.1111/j.1768-322x.1985.tb00354.x
PMID:2859901
Abstract

Six nervous system drugs which inhibited vegetative reproduction of S. cerevisiae arrested also mitotic division of C. utilis, C. albicans and C. tropicalis. Chlorpromazine and chlorpheniramine which proved to be the most effective, affected respiration and cytochrome biosynthesis. Electrophoretic bands with MW congruent to 100 K were faint in silver-stained electrophoregrams of proteins from cells grown in the presence of a sub-inhibitory concentration of chlorpromazine.

摘要

六种抑制酿酒酵母营养繁殖的神经系统药物也能阻止产朊假丝酵母、白色念珠菌和热带念珠菌的有丝分裂。事实证明，最有效的氯丙嗪和氯苯那敏会影响呼吸作用和细胞色素的生物合成。在亚抑制浓度的氯丙嗪存在下生长的细胞蛋白质的银染电泳图中，分子量与100K相当的电泳条带很淡。

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