Zhao Yang, Liu Dong, Proksch Peter, Yu Siwang, Lin Wenhan
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, DE-40225, Düsseldorf.
Chem Biodivers. 2017 Sep;14(9). doi: 10.1002/cbdv.201700236. Epub 2017 Aug 18.
TLC-DPPH guided fractionation of a sponge-associated fungus Truncatella angustata with a solid culture resulted in the isolation of five new α-pyrone-based analogues namely angupyrones A - E (1 - 5), and 3-ethyl-4-hydroxy-6-methyl-2-pyrone. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method, bulkiness rule, and specific rotation for the configurational assignments. Angupyrones A - E exhibited moderate antioxidant response element activation in HepG2C8 cells, while the preliminary structure-activity relationship was discussed.
通过TLC-DPPH法对一株与海绵共生的真菌窄截盘菌进行固体培养分级分离，得到了5个新的基于α-吡喃酮的类似物，即截盘菌素A - E（1 - 5），以及3-乙基-4-羟基-6-甲基-2-吡喃酮。通过广泛的光谱分析，包括改进的莫舍尔方法、空间位阻规则和比旋光度来确定其构型，从而确定了它们的结构。截盘菌素A - E在HepG2C8细胞中表现出适度的抗氧化反应元件激活，同时讨论了初步的构效关系。
