Liu Jing-Tang, Wu Wei, Cao Min-Jia, Yang Fan, Lin Hou-Wen
a Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , China.
Nat Prod Res. 2018 Aug;32(15):1791-1797. doi: 10.1080/14786419.2017.1402325. Epub 2017 Nov 13.
A new trienic α-pyrone derivative asteltoxin G (1) bearing a tetrahydrofuran ring and a new ochratoxin derivative named ochratoxin A (5), along with seven known compounds, were isolated from a sponge-derived fungus Aspergillus ochraceopetaliformis. The compounds (1-9) were evaluated on the basis of spectroscopic analyses and comparison with those of the reported data. The new compound ochratoxin A (5) exhibited anti-inflammatory activity against IL-6 and TNF-α expression of the LPS-induced THP-1 cells with inhibitory rates of 74.4 and 67.7% at concentration of 10 μM, respectively.
从一种源自海绵的真菌赭曲霉中分离出一种带有四氢呋喃环的新型三烯α-吡喃酮衍生物紫铆毒素G（1）、一种名为赭曲霉毒素A（5）的新型赭曲霉毒素衍生物以及七种已知化合物。通过光谱分析并与已报道数据进行比较对化合物（1-9）进行了评估。新化合物赭曲霉毒素A（5）对脂多糖诱导的THP-1细胞的IL-6和TNF-α表达具有抗炎活性，在浓度为10μM时抑制率分别为74.4%和67.7%。
