Fujii Tetsuro, Sakai Eiji, Takahashi Hirokazu, Yamada Eiji, Ohkubo Hidenori, Higurashi Takuma, Nakajima Atsushi
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0004, Japan.
Oncol Lett. 2017 Jun;13(6):4501-4504. doi: 10.3892/ol.2017.6003. Epub 2017 Apr 7.
Aberrant crypt foci (ACF) are considered as a useful surrogate biomarker for colorectal cancer, although their biological significance still remains controversial. We conducted this study to clarify whether differences in the ACF counting area might have led to the discrepancies in the ACF counts among previous reports. A endoscopist proficient in ACF counting performed high-magnification chromoscopic colonoscopy in 45 subjects and investigated the distribution of ACF in four bowel segments (middle Houston valve to the dentate line and distal rectum 0-5, 5-10 and 10-15 cm). We also investigated whether the patient physique might affect the distance from the middle Houston valve to the dentate line. The prevalence of ACF was 84% and most of the ACF (170/210, 81%) were located in the bowel segment from the middle Houston valve to the dentate line. The number of ACF was significantly correlated with the bowel segment in which the counting was performed: Dentate line to the middle Houston valve and distal rectum within 0-15 cm (r=0.94, P<0.001). The patient physique did not affect the distance from the middle Houston valve to the dentate line. In conclusion, the definition of the ACF counting area may not affect the results of ACF counting.
异常隐窝灶（ACF）被认为是结直肠癌一种有用的替代生物标志物，尽管其生物学意义仍存在争议。我们开展本研究以阐明ACF计数区域的差异是否可能导致先前报告中ACF计数的差异。一位精通ACF计数的内镜医师对45名受试者进行了高倍放大染色结肠镜检查，并研究了ACF在四个肠段（中休斯顿瓣膜至齿状线以及直肠远端0 - 5、5 - 10和10 - 15 cm）的分布情况。我们还研究了患者体型是否可能影响从中休斯顿瓣膜到齿状线的距离。ACF的患病率为84%，且大多数ACF（170/210，81%）位于从中休斯顿瓣膜到齿状线的肠段。ACF数量与进行计数的肠段显著相关：齿状线至中休斯顿瓣膜以及0 - 15 cm内的直肠远端（r = 0.94，P < 0.001）。患者体型不影响从中休斯顿瓣膜到齿状线的距离。总之，ACF计数区域的定义可能不会影响ACF计数结果。
