Rehman Hina, Raza Saleem, Aziz Sadaf, Ahmad Asad Maqbool, Tahir Sadia
Department of Radiology, Combined Military Hospital, Rawalpindi.
Nexus Diagnostics Laboratories, Rawalpindi.
J Coll Physicians Surg Pak. 2017 May;27(5):267-270.
To observe the diagnostic accuracy of elastography in detecting malignant breast lesion taking strain ratio of 4.8 and histopathology as gold standard.
Descriptive cross-sectional study.
Department of Diagnostic Radiology, from March to September 2015.
Atotal of 137 patients aged 20 to 60 years with clinically palpable breast lump of any size for at least one month duration were included in this study. Patients with purely cystic lesions and those on chemotherapy or hormonal therapy were excluded. Each patient was subjected to sonoelastography followed by ultrasound guided trucut biopsy. The strain ratio cut off value of 4.8 was used to differentiate benign from malignant lesion. Consultant histopathologist's report upon the biopsy specimens was obtained. Results of sonoelastography were compared with histopathology reports.
Mean age was 38.20 ±10.63 years. The size of the lesion ranged from 2.0 to 6.0 cm, a mean = 3.97 ±1.26 cm. The duration since the lump was noticed ranged from 12 weeks (3 months) to 20 weeks (5 months) with a mean of 15.09 ±2.56 weeks. Forty-one (29.9%) lesions were labelled malignant on sonoelastography while the actual number of malignant lesions was 35 (25.5%) on histopathology. When the results of sonoelastography were cross-tabulated with histopathology results, the number of TP(true positive), FN (false negative), FP(false positive) and TN (True negative) were 31, 4, 10 and 92 cases, respectively. It yielded 88.57% sensitivity, 90.20% specificity, 75.61% positive predictive value, 95.83% negative predictive value, 89.78% accuracy for sonoelastography in the diagnosis of malignant breast lesion taking histopathology as gold standard with an observed prevalence of malignant breast mass to be 25.55%.
Using a strain ratio of 4.8, sonoelastography was found to be 88.57% sensitive, 90.20% specific, and 89.78% accurate in the diagnosis of malignant breast masses.
以4.8的应变率和组织病理学为金标准，观察弹性成像技术检测乳腺恶性病变的诊断准确性。
描述性横断面研究。
2015年3月至9月，诊断放射科。
本研究纳入了137例年龄在20至60岁之间、临床可触及任何大小乳腺肿块且持续至少1个月的患者。排除纯囊性病变患者以及正在接受化疗或激素治疗的患者。对每位患者进行超声弹性成像检查，随后进行超声引导下的 Trucut 活检。采用4.8的应变率临界值来区分良性和恶性病变。获取了病理科会诊医师对活检标本的报告。将超声弹性成像检查结果与组织病理学报告进行比较。
平均年龄为38.20±10.63岁。病变大小范围为2.0至6.0厘米，平均为3.97±1.26厘米。自发现肿块以来的时间范围为12周（3个月）至20周（5个月），平均为15.09±2.56周。超声弹性成像检查标记为恶性的病变有41例（29.9%），而组织病理学检查显示实际恶性病变数量为35例（25.5%）。当将超声弹性成像检查结果与组织病理学结果进行交叉制表时，真阳性（TP）、假阴性（FN）、假阳性（FP）和真阴性（TN）的病例数分别为31、4、10和92例。以组织病理学为金标准，超声弹性成像技术在诊断乳腺恶性病变中的敏感性为88.57%，特异性为90.20%，阳性预测值为75.61%，阴性预测值为95.83%，准确性为89.78%，观察到的乳腺恶性肿块患病率为25.55%。
采用4.8的应变率时，超声弹性成像技术在诊断乳腺恶性肿块方面的敏感性为88.57%，特异性为90.20%，准确性为89.78%。
