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[神经性厌食症中去甲肾上腺素能通路紊乱。结果]

[Disorders of noradrenergic pathways in anorexia nervosa. Results].

作者信息

Lang F, Estour B, Peyrin L, Perrier B, Digonnet C, Rousset H, Pellet J

出版信息

Encephale. 1985 Jan-Feb;11(1):13-7.

PMID:2859980
Abstract

Twelve patients suffering from mental anorexia were examined on clinical and biological grounds, based on the hypothesis of the functional depression of the noradrenergic track. The initial values of MHPG and of catecholamines were below normal. The quantitative results for depression and retardation were lessened significantly under beta-stimulant treatment. Only glucuro-conjugate MHPG excretion increased significantly, but the MHPG values were much lower than normal at the end of the treatment. The correlations between biochemical and behavioural parameters were worth noticing as far as the retardation scale was concerned. The present study shows the advantage of the dexamethasone suppression test and of the response of TSH under TRH.

摘要

基于去甲肾上腺素能通路功能减退的假说,对12例精神性厌食患者进行了临床和生物学检查。MHPG和儿茶酚胺的初始值低于正常水平。在β-兴奋剂治疗下,抑郁和迟缓的定量结果显著减轻。只有葡糖醛酸结合型MHPG排泄显著增加,但治疗结束时MHPG值仍远低于正常水平。就迟缓量表而言,生化参数与行为参数之间的相关性值得关注。本研究显示了地塞米松抑制试验和促甲状腺激素释放激素(TRH)刺激下促甲状腺激素(TSH)反应的优势。

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