Iasnetsov V S, Vishnevskiĭ S E
Farmakol Toksikol. 1985 Mar-Apr;48(2):18-21.
Experiments on rats with experimental brain edema under water intoxication were made to study the effects of the neuroleptics aminazine and propazine, the central M-cholinoblocker amizyl and the alpha-adrenoblocker phentolamine on the time-course of the recovery of cortical electric activity after passing of the wave of Leao's spreading depression (SD). The drugs under study were demonstrated to have antiedematous properties under water intoxication and to make to a considerable degree for disorders in the processes of the recovery of cortical electrogenesis after SD. It is assumed that the action of the drugs on the electrophysiological parameters under study is associated with their effects on metabolic processes and with the presence of antiedematous properties.
在水中毒状态下对患有实验性脑水肿的大鼠进行实验，以研究抗精神病药物氯丙嗪和丙嗪、中枢性M胆碱阻滞剂阿米齐尔和α肾上腺素能阻滞剂酚妥拉明对莱奥扩散性抑制波（SD）过后皮质电活动恢复的时间进程的影响。研究表明，所研究的药物在水中毒状态下具有抗水肿特性，并在很大程度上弥补了SD后皮质电发生恢复过程中的紊乱。据推测，这些药物对所研究的电生理参数的作用与其对代谢过程的影响以及抗水肿特性的存在有关。
