Rondelet Grégoire, Wouters Johan
Department of Chemistry, NAmur MEdicine & Drug Innovation Center (NAMEDIC-NARILIS), University of Namur, 61 rue de Bruxelles, B-5000 Namur, Belgium.
Department of Chemistry, NAmur MEdicine & Drug Innovation Center (NAMEDIC-NARILIS), University of Namur, 61 rue de Bruxelles, B-5000 Namur, Belgium.
Biochimie. 2017 Aug;139:137-147. doi: 10.1016/j.biochi.2017.06.003. Epub 2017 Jun 6.
Epigenetic modifications modulate chromatin states to regulate gene expression. Among them, DNA methylation and histone modifications play a crucial role in the establishment of the epigenome. In cancer, these epigenetic events may act in concert to repress tumor suppressor genes or promote oncogenic pathways. In the context of cancer initiation and progression, recruitment of DNA (cytosine-5)-methyltransferases to specific genomic regions is mainly mediated by histone epigenetic marks, transcription factors and co-regulators as part of a dynamic process. Herein, we will review these mechanisms and present state-of-the-art of DNA methylation, treatment and development of epigenetic cancer therapies targeting this epigenetic modification.
表观遗传修饰可调节染色质状态以调控基因表达。其中，DNA甲基化和组蛋白修饰在表观基因组的建立中起着关键作用。在癌症中，这些表观遗传事件可能协同作用，抑制肿瘤抑制基因或促进致癌途径。在癌症发生和发展的背景下，DNA（胞嘧啶-5）-甲基转移酶招募至特定基因组区域主要由组蛋白表观遗传标记、转录因子和共调节因子介导，这是一个动态过程的一部分。在此，我们将综述这些机制，并介绍针对这种表观遗传修饰的DNA甲基化、治疗方法及表观遗传癌症疗法的发展现状。
