英国角膜移植术后2至5年视觉结果的稳定性。
Stability of visual outcome between 2 and 5 years following corneal transplantation in the UK.
作者信息
Chow Sing-Pey, Hopkinson Cathy L, Tole Derek M, Jones Mark N, Cook Stuart D, John Armitage W
机构信息
Cornea and External Disease Service, Bristol Eye Hospital, Bristol, UK.
Tissue and Eye Services, National Health Service Blood and Transplant (NHSBT), Bristol, UK.
出版信息
Br J Ophthalmol. 2018 Jan;102(1):37-41. doi: 10.1136/bjophthalmol-2016-310129. Epub 2017 Jun 9.
BACKGROUND AND AIMS
Many studies of corneal transplantation focus on graft failure or rejection as endpoints, or report visual outcomes at one postoperative time point. We aimed to study the stability of visual outcomes between 2 and 5 years following corneal transplantation.
METHODS
All patients with keratoconus (868) or Fuchs endothelial dystrophy (FED) (569) receiving their first corneal transplant for visual purposes in the UK between January 2003 and December 2009 were included. The probability of visual improvement or deterioration (gain or loss of ≥2 Snellen lines, respectively) between 2 and 5 years after keratoplasty was modelled by multivariable logistic regression.
RESULTS
The majority of keratoconus patients with a penetrating keratoplasty (PK) or deep anterior lamellar keratoplasty maintained their visual acuity (651/868; 75%) while 15% (133/868) improved and 10% (84/868) deteriorated. Similarly, most patients with FED who received a PK maintained their vision (395/569; 70%) while 18% (105/569) improved and 12% (68/569) deteriorated.
背景与目的
许多角膜移植研究将移植失败或排斥反应作为终点指标，或者仅报告术后某一时刻的视力结果。我们旨在研究角膜移植术后2至5年视力结果的稳定性。
方法
纳入2003年1月至2009年12月期间在英国因视力问题接受首次角膜移植的所有圆锥角膜患者（868例）或Fuchs内皮营养不良（FED）患者（569例）。通过多变量逻辑回归对角膜移植术后2至5年视力改善或恶化（分别为视力增加或降低≥2行Snellen视力表）的概率进行建模。
结果
大多数接受穿透性角膜移植术（PK）或深前板层角膜移植术的圆锥角膜患者保持了视力（651/868；75%），而15%（133/868）的患者视力提高，10%（84/868）的患者视力下降。同样，大多数接受PK的FED患者保持了视力（395/569；70%）。而18%（105/569）的患者视力提高，12%（68/569）的患者视力下降。
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