使用一种新型长效生长抑素类似物治疗胰腺内分泌肿瘤患者的症状和肽反应。
Treatment of patients with pancreatic endocrine tumours using a new long-acting somatostatin analogue symptomatic and peptide responses.
作者信息
Wood S M, Kraenzlin M E, Adrian T E, Bloom S R
出版信息
Gut. 1985 May;26(5):438-44. doi: 10.1136/gut.26.5.438.
Abstract
Seven patients with gut and pancreatic endocrine tumours have been treated with a long acting somatostatin analogue (SMS 201-995), given as a twice daily subcutaneous injection. This produced dramatic improvement in their endocrine related symptoms, in association with a fall in circulating tumour peptides. One of these patients has now been treated for seven months with this analogue which has controlled his previously life threatening diarrhoea caused by a malignant VIP secreting tumour. He gives his own injections twice daily, and has returned to a full and active life. This is a promising agent both for acute treatment of peptide hypersecretion, and for the long term management of some patients who are unresponsive to other available therapy.
摘要
7例肠道和胰腺内分泌肿瘤患者接受了长效生长抑素类似物（SMS 201-995）治疗，采用每日两次皮下注射给药。这使其与内分泌相关的症状得到显著改善，同时循环肿瘤肽水平下降。其中1例患者已使用该类似物治疗7个月，该药物控制了其先前由分泌血管活性肠肽的恶性肿瘤引起的危及生命的腹泻。他每天自行注射两次，现已恢复到充实而活跃的生活状态。这种药物对于肽分泌过多的急性治疗以及对其他现有治疗无反应的部分患者的长期管理都是一种很有前景的药物。
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