长效生长抑素类似物对胰腺内分泌肿瘤分泌的抑制作用

Suppression of pancreatic endocrine tumour secretion by long-acting somatostatin analogue.

作者信息

Long R G, Barnes A J, Adrian T E, Mallinson C N, Brown M R, Vale W, Rivier J E, Christofides N D, Bloom S R

出版信息

Lancet. 1979 Oct 13;2(8146):764-7. doi: 10.1016/s0140-6736(79)92115-9.

Abstract

A new long-acting octapeptide analogue of somatostatin, Des AA1,2,4,5,12,13 D Try8 somatostatin, has been tested in 8 patients with pancreatic endocrine tumours. The analogue given subcutaneously suppressed the tumour-derived hormones in patients with insulinomas, glucagonomas, and gastrinomas for up to 24 h. The prolonged action appeared to be the result of slow release from the injection site. No side-effects were observed. Studies of long-term administration of this new peptide are now warranted.

摘要

一种新型生长抑素长效八肽类似物，去丙氨酸1、2、4、5、12、13，右旋色氨酸8生长抑素，已在8例胰腺内分泌肿瘤患者中进行了测试。皮下注射该类似物可使胰岛素瘤、胰高血糖素瘤和胃泌素瘤患者体内的肿瘤源性激素抑制长达24小时。作用时间延长似乎是由于从注射部位缓慢释放所致。未观察到副作用。现在有必要对这种新肽进行长期给药研究。