促性腺激素释放激素激动剂扳机后发生卵巢过度刺激综合征——考虑异位妊娠。
Ovarian hyperstimulation syndrome following GnRH agonist trigger-think ectopic.
机构信息
Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel.
Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
J Assist Reprod Genet. 2017 Sep;34(9):1161-1165. doi: 10.1007/s10815-017-0960-0. Epub 2017 Jun 9.
Abstract
PURPOSE
This study aims to report a case of ovarian hyperstimulation syndrome (OHSS) following GnRH agonist trigger for final follicular maturation.
METHODS
This study is a retrospective chart review.
RESULTS
We report the first case of OHSS following GnRH agonist trigger for final follicular maturation and freeze-all, masking extrauterine pregnancy (EUP). The present case report elucidates the feasibility of stimulating and recruiting ovarian follicles yielding mature oocytes during early pregnancy and the ability of GnRH agonist to trigger final follicular maturation during pregnancy, in the presence of high progesterone and hCG levels.
CONCLUSIONS
Since OHSS almost always develops after hCG administration or in early pregnancy, its occurrence following GnRH agonist trigger should alert physician to search for either an inadvertent administration of exogenous hCG, or the endogenous secretion of hCG by pregnancy, e.g. EUP, or as part of a paraneoplastic syndrome.
摘要
目的
本研究旨在报告一例 GnRH 激动剂触发最终卵泡成熟后发生卵巢过度刺激综合征（OHSS）的病例。
方法
本研究是一项回顾性图表审查。
结果
我们报告了首例 GnRH 激动剂触发最终卵泡成熟和冷冻所有以掩盖异位妊娠（EUP）后发生 OHSS 的病例。本病例报告阐明了在高孕激素和 hCG 水平存在的情况下，在妊娠早期刺激和募集卵巢卵泡以产生成熟卵母细胞的可行性，以及 GnRH 激动剂在妊娠期间触发最终卵泡成熟的能力。
结论
由于 OHSS 几乎总是在 hCG 给药后或在妊娠早期发生，因此 GnRH 激动剂触发后发生 OHSS 应提醒医生寻找外源性 hCG 的意外给药，或妊娠时 hCG 的内源性分泌，例如 EUP，或作为副肿瘤综合征的一部分。
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