Zivanovic Mirjana, Atanasković-Marković Marina, Medjo Biljana, Gavrović-Jankulović Marija, Smiljanić Katarina, Tmušić Vladimir, Djurić Vojislav
Special Hospital "Sokobanja", Sokobanja, Serbia.
Medical Faculty, University of Belgrade, Belgrade, Serbia AND University Children's Hospital of Belgrade, Belgrade, Serbia.
Iran J Allergy Asthma Immunol. 2017 Apr;16(2):127-132.
IgE- mediated food allergy affects 6-8% of children. Our study aimed to define the correlations between the results obtained with skin prick tests (SPTs) using commercial extracts and fresh foods, and the correlations between these result and those obtained with specific IgE (sIgE) and/ or challenge. Children aged from 2 months to 6 years were recruited prospectively. Overall 571 children were positive to one food. In all children we performed SPT using commercial extracts of suspected food and fresh foods and sIgE. If SPT and sIgE test results did not correspond to the history, we performed open oral food challenge. Sensitivity of SPT with commercial extracts for all tested food was poor (3-35%), while sensitivity of fresh food skin prick tests (FFSPT) was excellent (50-100%), and showed correlation with open oral food challenge (p<0.001). Our results suggest that fresh food extracts are more effective in detecting sensitization and with levels of sIgE greater than class 3 could predict clinical reactivity, without the need for potentially hazardous food challenges.
IgE介导的食物过敏影响6%至8%的儿童。我们的研究旨在确定使用市售提取物和新鲜食物进行皮肤点刺试验（SPT）所获得的结果之间的相关性，以及这些结果与通过特异性IgE（sIgE）和/或激发试验所获得结果之间的相关性。前瞻性招募了年龄在2个月至6岁之间的儿童。共有571名儿童对一种食物呈阳性反应。我们对所有儿童使用疑似食物的市售提取物、新鲜食物以及sIgE进行了SPT。如果SPT和sIgE检测结果与病史不符，我们进行了开放性口服食物激发试验。使用市售提取物进行SPT对所有受试食物的敏感性较差（3% - 35%），而新鲜食物皮肤点刺试验（FFSPT）的敏感性极佳（50% - 100%），且与开放性口服食物激发试验具有相关性（p<0.001）。我们的结果表明，新鲜食物提取物在检测致敏方面更有效，且sIgE水平大于3级可预测临床反应性，无需进行有潜在危险的食物激发试验。
