Allam A, Thomsen A R, Gothwal M, Saha D, Maurer J, Brunner T B
Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; Clinical Oncology and Nuclear Medicine Department, Assiut University Hospitals, Egypt.
Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pancreatology. 2017 Jul-Aug;17(4):514-522. doi: 10.1016/j.pan.2017.05.390. Epub 2017 May 27.
Pancreatic stellate cells are stromal cells that have multiple physiological functions such as the production of extracellular matrix, stimulation of amylase secretion, phagocytosis and immunity. In pancreatic cancer, stellate cells exhibit a different myofibroblastic-like morphology with the expression of alpha-smooth muscle actin, the activated form is engaged in several mechanisms that support tumorigenesis and cancer invasion and progression. In contrast to the aforementioned observations, eliminating the stromal cells that are positive for alpha-smooth muscle actin resulted in immune-evasion of the cancer cells and resulted in worse prognosis in animal models. Understanding the cancer-stromal signaling in pancreatic adenocarcinoma will provide novel strategies for therapy. Here we provide an updated review of studies that handle the topic "pancreatic stellate cells in cancer" and recent experimental approaches that can be the base for future directions in therapy.
胰腺星状细胞是一种基质细胞，具有多种生理功能，如产生细胞外基质、刺激淀粉酶分泌、吞噬作用和免疫功能。在胰腺癌中，星状细胞呈现出不同的肌成纤维细胞样形态，伴有α平滑肌肌动蛋白的表达，其活化形式参与了多种支持肿瘤发生、癌症侵袭和进展的机制。与上述观察结果相反，消除α平滑肌肌动蛋白阳性的基质细胞会导致癌细胞的免疫逃逸，并在动物模型中导致更差的预后。了解胰腺腺癌中的癌-基质信号传导将为治疗提供新的策略。在此，我们提供了一篇关于“癌症中的胰腺星状细胞”这一主题的研究综述以及可作为未来治疗方向基础的最新实验方法。
