Csernansky J G, Kaplan J, Hollister L E
J Nerv Ment Dis. 1985 Jun;173(6):325-31. doi: 10.1097/00005053-198506000-00001.
The authors review the many clinical and pharmacological factors that affect neuroleptic response and complicate the classification of schizophrenic patients into responders and nonresponders. The subtyping of patients on the basis of "positive" or "negative" symptoms and the presence or absence of brain atrophy may be particularly useful in predicting neuroleptic response. There is also a promising relationship between plasma neuroleptic concentrations and response. The concept of supersensitivity psychosis is introduced as a reason for apparent nonresponse in some patients. In others, neuroleptic responsivity may be inherently variable. The authors make suggestions for future research in neuroleptic response.
作者回顾了许多影响抗精神病药物反应并使将精神分裂症患者分为反应者和无反应者的分类复杂化的临床和药理学因素。根据“阳性”或“阴性”症状以及脑萎缩的有无对患者进行亚型分类，可能对预测抗精神病药物反应特别有用。血浆抗精神病药物浓度与反应之间也存在有前景的关系。引入了超敏性精神病的概念，作为一些患者明显无反应的原因。在其他患者中，抗精神病药物反应性可能本来就存在差异。作者对未来抗精神病药物反应的研究提出了建议。
