精神分裂症患者的抗精神病药物治疗。作用机制及临床意义。
Neuroleptic treatment of patients with schizophrenia. Mechanisms of action and clinical significance.
作者信息
Wiesel F A
机构信息
Department of Psychiatry, Uppsala University, Sweden.
出版信息
Br J Psychiatry Suppl. 1994 Apr(23):65-70.
PMID:7913610
Abstract
Neuroleptic drugs have been used in the treatment of schizophrenic patients for 40 years. In the 1960s it was proposed that the mechanism of action was a blockade of dopamine receptors; in vivo studies give strong evidence that a blockade of D2 dopamine receptors mediate the antipsychotic effect of classic neuroleptics. However, the antipsychotic effect of neuroleptics is synergistic with family treatment and social-skills training.
摘要
抗精神病药物已用于治疗精神分裂症患者40年了。在20世纪60年代，有人提出其作用机制是阻断多巴胺受体；体内研究提供了强有力的证据，表明阻断D2多巴胺受体介导了经典抗精神病药物的抗精神病作用。然而，抗精神病药物的抗精神病作用与家庭治疗和社交技能训练具有协同作用。
Zotero 插件