Haalboom J R, Deenstra M, Struyvenberg A
Lancet. 1985 May 18;1(8438):1125-7. doi: 10.1016/s0140-6736(85)92432-8.
The effect of inhalation of fenoterol, a beta 2-agonist, on plasma potassium was studied in four groups of four healthy young subjects. Group I received 3 times 2 puffs (0.2 mg fenoterol/puff), group II 3 times 3 puffs, and group III 3 times 4 puffs. Group IV received 3 times 4 puffs of a placebo, according to the group III schedule. The puffs were given at 30-min intervals. Plasma potassium levels decreased significantly in subjects who received fenoterol: the decrease was 0.4 +/- 0.3 (SD) mmol/l in group I, 0.5 +/- 0.2 mmol/l in group II and 0.9 +/- 0.1 mmol/l in group III. In the placebo group plasma potassium levels were unchanged. Inhalation of beta 2-agonists may be dangerous, especially in patients under stress--eg, during an acute asthmatic attack, when the plasma potassium concentration would already be subnormal as the result of raised circulating adrenaline levels.
在四组每组四名健康年轻受试者中研究了吸入β2激动剂非诺特罗对血浆钾的影响。第一组接受3次，每次2喷（每喷含0.2mg非诺特罗）；第二组接受3次，每次3喷；第三组接受3次，每次4喷。第四组按照第三组的方案接受3次，每次4喷的安慰剂。喷药间隔为30分钟。接受非诺特罗的受试者血浆钾水平显著降低：第一组降低0.4±0.3（标准差）mmol/L，第二组降低0.5±0.2mmol/L，第三组降低0.9±0.1mmol/L。安慰剂组血浆钾水平未改变。吸入β2激动剂可能有危险，尤其是在应激状态下的患者中——例如，在急性哮喘发作期间，此时由于循环肾上腺素水平升高，血浆钾浓度可能已经低于正常水平。
