基因Ser219Gly多态性与静脉血栓栓塞症：对9494名受试者的荟萃分析
Gene Ser219Gly Polymorphism and Venous Thromboembolism: A Meta-Analysis of 9,494 Subjects.
作者信息
Li Yan-Yan, Wu Jing-Jing, Yang Xin-Xing, Geng Hong-Yu, Gong Ge, Kim Hyun Jun
机构信息
Department of Gerontology, First Affiliated Hospital of Nanjing Medical UniversityNanjing, China.
Department of Nephrology, First Affiliated Hospital of Nanjing Medical UniversityNanjing, China.
出版信息
Front Physiol. 2017 May 26;8:339. doi: 10.3389/fphys.2017.00339. eCollection 2017.
Although gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidate the potential relationship between the gene Ser219Gly polymorphism and VTE. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed or random effect models. The current meta-analysis suggested that there was a significant association between gene Ser219Gly polymorphism and VTE under allelic (OR: 1.42, 95% CI: 1.21-1.66, = 1.30 × 10), recessive (OR: 2.02, 95% CI: 1.44-2.85, = 5.35 × 10), homozygous (OR: 2.24, 95% CI: 1.59-3.16, = 3.66 × 10), and additive genetic models (OR: 1.63, 95% CI: 1.30-2.04, = 2.24 × 10). gene Ser219Gly polymorphism was associated with an elevated risk of VTE and the Gly residue carriers of the gene might be predisposed to VTE.
尽管基因Ser219Gly多态性与静脉血栓栓塞症（VTE）易感性有关，但尚未达成明确共识。对来自13项独立研究的9494名受试者进行了荟萃分析，以更好地阐明基因Ser219Gly多态性与VTE之间的潜在关系。采用固定效应或随机效应模型评估合并比值比（OR）及其相应的95%置信区间（CI）。当前的荟萃分析表明，在等位基因（OR：1.42，95%CI：1.21 - 1.66，P = 1.30×10⁻⁵）、隐性（OR：2.02，95%CI：1.44 - 2.85，P = 5.35×10⁻⁴）、纯合子（OR：2.24，95%CI：1.59 - 3.16，P = 3.66×10⁻⁴）和加性遗传模型（OR：1.63，95%CI：1.30 - 2.04，P = 2.24×10⁻³）下，基因Ser219Gly多态性与VTE之间存在显著关联。基因Ser219Gly多态性与VTE风险升高有关，该基因的Gly残基携带者可能易患VTE。
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