Li Yan-Yan, Wang Hui, Yang Xin-Xing, Geng Hong-Yu, Gong Ge, Lu Xin-Zheng
Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Cardiovasc Med. 2020 Nov 5;7:582865. doi: 10.3389/fcvm.2020.582865. eCollection 2020.
Research has shown a possible relationship between the E670G polymorphism of the () gene and an increased risk of coronary artery disease (CAD). However, there is no clear consensus on the subject because of conflicting results in the literature. The current meta-analysis was performed to better elucidate the potential relationship between the gene E670G polymorphism and CAD. There were 5,484 subjects from 13 individual studies who were included in the current meta-analysis. The fixed- or random-effects models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). The current meta-analysis found a significant association between gene E670G polymorphism and CAD under allelic (OR = 1.79, 95% CI = 1.42-2.27, = 1.00 × 10), dominant (OR = 2.16, 95% CI = 1.61-2.89, = 2.22 × 10), heterozygous (OR = 2.02, 95% CI = 1.55-2.64, = 2.47 × 10), and additive genetic models (OR = 1.92, 95% CI = 1.49-2.49, = 6.70 × 10). gene E670G polymorphism was associated with an elevated risk of CAD, especially in the Chinese population. More specifically, carriers of the G allele carriers of the gene may be predisposed to developing CAD.
研究表明，（）基因的E670G多态性与冠状动脉疾病（CAD）风险增加之间可能存在关联。然而，由于文献结果相互矛盾，关于这一主题尚无明确共识。进行当前的荟萃分析是为了更好地阐明该基因E670G多态性与CAD之间的潜在关系。本荟萃分析纳入了来自13项独立研究的5484名受试者。采用固定效应或随机效应模型评估合并比值比（OR）及其相应的95%置信区间（CI）。当前的荟萃分析发现，在等位基因（OR = 1.79，95%CI = 1.42 - 2.27，= 1.00×10）、显性（OR = 2.16，95%CI = 1.61 - 2.89，= 2.22×10）、杂合子（OR = 2.02，95%CI = 1.55 - 2.64，= 2.47×10）和加性遗传模型（OR = 1.92，95%CI = 1.49 - 2.49，= 6.70×10）下，该基因E670G多态性与CAD之间存在显著关联。该基因E670G多态性与CAD风险升高相关，尤其是在中国人群中。更具体地说，该基因G等位基因携带者可能易患CAD。
