Li Yan-Yan, Lu Xin-Zheng, Wang Hui, Zhou Yan-Hong, Yang Xin-Xing, Geng Hong-Yu, Gong Ge, Kim Hyun Jun
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Genet. 2018 Apr 4;9:106. doi: 10.3389/fgene.2018.00106. eCollection 2018.
Presence of the β gene Trp64Arg (T64A) polymorphism may be associated with an increased susceptibility for essential hypertension (EH). A clear consensus, however, has yet to be reached. To further elucidate the relationship between the gene Trp64Arg polymorphism and EH, a meta-analysis of 9,555 subjects aggregated from 16 individual studies was performed. The combined odds ratios (ORs) and their corresponding 95% confidence intervals (CI) were evaluated using either a random or fixed effect model. We found a marginally significant association between gene Trp64Arg polymorphism and EH in the whole population under the additive genetic model (OR: 1.200, 95% CI: 1.00-1.43, = 0.049). Association within the Chinese subgroup, however, was significant under allelic (OR: 1.150, 95% CI: 1.002-1.320, = 0.046), dominant (OR: 1.213, 95% CI: 1.005-1.464, = 0.044), heterozygous (OR: 1.430, 95% CI:1.040-1.970, = 0.03), and additive genetic models (OR: 1.280, 95% CI: 1.030-1.580, = 0.02). A significant association was also found in the Caucasian subgroup under allelic (OR: 1.850, 95% CI: 1. 260-2.720, = 0.002), dominant (OR: 2.004, 95% CI: 1.316-3.052, = 0.001), heterozygous (OR: 2.220, 95% CI: 1.450-3.400, = 0.0002), and additive genetic models (OR: 2.000, 95% CI: 1. 330-3.010, = 0.0009). The presence of the gene Trp64Arg polymorphism is positively associated with EH, especially in the Chinese and Caucasian population. The Arg allele carriers of gene Trp64Arg polymorphism may be at an increased risk for developing EH.
β基因Trp64Arg（T64A）多态性的存在可能与原发性高血压（EH）易感性增加有关。然而，尚未达成明确的共识。为了进一步阐明β基因Trp64Arg多态性与EH之间的关系，对来自16项个体研究汇总的9555名受试者进行了荟萃分析。使用随机或固定效应模型评估合并比值比（OR）及其相应的95%置信区间（CI）。我们发现在加性遗传模型下，β基因Trp64Arg多态性与整个人群中的EH之间存在边缘显著关联（OR：1.200，95%CI：1.00 - 1.43，P = 0.049）。然而，在中国亚组中，在等位基因（OR：1.150，95%CI：1.002 - 1.320，P = 0.046）、显性（OR：1.213，95%CI：1.005 - 1.464，P = 0.044）、杂合子（OR：1.430，95%CI：1.040 - 1.970，P = 0.03）和加性遗传模型（OR：1.280，95%CI：1.030 - 1.580，P = 0.02）下存在显著关联。在白种人亚组中，在等位基因（OR：1.850，95%CI：1.260 - 2.720，P = 0.002）、显性（OR：2.004，95%CI：1.316 - 3.052，P = 0.001）、杂合子（OR：2.220，95%CI：1.450 - 3.400，P = 0.0002）和加性遗传模型（OR：2.000，95%CI：1.330 - 3.010，P = 0.0009）下也发现了显著关联。β基因Trp64Arg多态性的存在与EH呈正相关，尤其是在中国和白种人群体中。β基因Trp64Arg多态性的Arg等位基因携带者患EH的风险可能增加。
