Napolitano Andrea, Carbone Michele
Department of Thoracic Oncology, University of Hawai i Cancer Center, 96826 Honolulu, HI, USA.
Trends Cancer. 2016 Sep;2(9):467-474. doi: 10.1016/j.trecan.2016.07.004.
Malignant mesothelioma is an aggressive cancer largely associated with asbestos exposure. In this review, we will discuss the significant advancements in our understanding of its genetics and molecular biology and their translational relevance. Remarkable findings included the discovery of germline and somatic mutations of BRCA1 associated protein-1 (BAP1) in patients, and the genome-wide characterization of pathways altered in mesothelioma that could be potentially exploited to design novel therapeutic approaches. Nevertheless, the clinical translation of these molecular findings has been slow and insufficient. In order to rapidly move translation from the bench to the bedside, we believe that cooperative research efforts have to be further endorsed and promoted at all levels.
恶性间皮瘤是一种侵袭性癌症，主要与接触石棉有关。在本综述中，我们将讨论在其遗传学和分子生物学理解方面取得的重大进展及其转化相关性。显著的发现包括在患者中发现BRCA1相关蛋白-1（BAP1）的种系和体细胞突变，以及对间皮瘤中改变的通路进行全基因组表征，这些通路有可能被用于设计新的治疗方法。然而，这些分子发现的临床转化一直缓慢且不足。为了迅速将研究从实验室转化到临床应用，我们认为必须在各级进一步支持和推动合作研究工作。
