Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
Department of General Surgery, Sir Run Run Shaw Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310016, China.
Dis Markers. 2019 Feb 12;2019:4183157. doi: 10.1155/2019/4183157. eCollection 2019.
Malignant mesothelioma (MM) is a rare, aggressive, and highly lethal cancer that is substantially induced by exposure to asbestos fibers. High-mobility group box 1 (HMGB1) is an intriguing proinflammatory molecule involved in MM. In this review, we describe the possible crucial roles of HMGB1 in carcinogenic mechanisms based on and experimental evidence and outline the clinical findings of epidemiological investigations regarding the possible roles of HMGB1 as a biomarker for MM. We conclude that novel strategies targeting HMGB1 may suppress MM cells and interfere with asbestos-induced inflammation.
恶性间皮瘤（MM）是一种罕见的、侵袭性的、高度致命的癌症，主要由暴露于石棉纤维引起。高迁移率族蛋白 B1（HMGB1）是一种引人关注的促炎分子，与 MM 有关。在这篇综述中，我们根据 和 实验证据描述了 HMGB1 在致癌机制中可能的关键作用，并概述了关于 HMGB1 作为 MM 生物标志物的可能作用的流行病学研究的临床发现。我们的结论是，针对 HMGB1 的新策略可能抑制 MM 细胞并干扰石棉诱导的炎症。
