Ota Koji, Adar Tony, Dover Laura, Khachemoune Amor
a SUNY Downstate Medical Center , Brooklyn , NY , USA.
b Department of Dermatology , SUNY Downstate Medical Center , Brooklyn , NY , USA.
J Dermatolog Treat. 2018 Mar;29(2):170-175. doi: 10.1080/09546634.2017.1341617. Epub 2017 Jun 30.
Electronic brachytherapy (EBT) has seen a significant rise in use over the past few years in treating non-melanoma skin cancer (NMSC). However, the current literature in EBT remains scarce. Existing data on high-dose rate brachytherapy (HDR-BT) with surface applicators is often used to justify its efficacy and safety. In this review we study the two treatment modalities on their efficacy in treating NMSC and we explore the reasons behind the recent uprise in EBT. A literature review using PubMed was performed for articles published until January 2017 studying efficacy of HDR-BT and EBT for treating NMSC. HDR-BT demonstrated effective local control ranging from 96.2% to 100% up to 66 months of follow-up with acceptable cosmesis. For EBT, local control rates ranged from 90% to 100% with generally favorable tolerance and cosmesis outcome after roughly one year. While longer term data on EBT is needed, its short term efficacy shows promise as a possible alternative to surgery or other radiation therapy in a select group of patients.
在过去几年中，电子近距离放射治疗（EBT）在治疗非黑色素瘤皮肤癌（NMSC）方面的应用显著增加。然而，目前关于EBT的文献仍然很少。现有的关于使用表面施源器进行高剂量率近距离放射治疗（HDR-BT）的数据常被用来证明其有效性和安全性。在本综述中，我们研究了这两种治疗方式在治疗NMSC方面的疗效，并探讨了EBT近期兴起的原因。我们利用PubMed进行文献综述，检索截至2017年1月发表的关于HDR-BT和EBT治疗NMSC疗效的文章。HDR-BT在长达66个月的随访中显示出有效的局部控制率，范围从96.2%至100%，美容效果可接受。对于EBT，在大约一年后局部控制率范围为90%至100%，总体耐受性和美容效果良好。虽然需要关于EBT的长期数据，但其短期疗效表明，在特定患者群体中，它有望成为手术或其他放射治疗的一种可能替代方案。
