皮内流感疫苗的免疫原性、安全性和耐受性。
Immunogenicity, safety and tolerability of intradermal influenza vaccines.
机构信息
a Department of Medicine, the University of Hong Kong, Queen Mary Hospital , Hong Kong, Hong Kong Special Administrative Region , China.
b Carol Yu Centre for Infection and Division of Infectious Disease, State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology , the University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong Special Administrative Region , China.
出版信息
Hum Vaccin Immunother. 2018 Mar 4;14(3):565-570. doi: 10.1080/21645515.2017.1328332. Epub 2017 Jul 6.
Abstract
Intradermal influenza vaccination has been studied for more than 80 y. The revived interest in this strategy of vaccination is a result of the innovative technologies in needle design allowing more precise injection and making the device easier to use. Furthermore, clinical trials on these novel devices have demonstrated significant dose sparing effects, improved immunogenicity and very few adverse effects. This review compares intradermal vaccination with various devices with subcutaneous and intramuscular vaccination. We also discussed the role of topical adjuvant before intradermal vaccination.
摘要
皮内流感疫苗接种的研究已经超过 80 年。人们对这种疫苗接种策略重新产生兴趣，是因为在针具设计方面的创新技术使得注射更加精确，操作更加简便。此外，这些新型器械的临床试验表明，皮内接种具有显著的节省剂量、提高免疫原性和极少不良反应的效果。本文比较了各种皮内接种器械与皮下和肌肉接种的效果。我们还讨论了皮内接种前局部应用佐剂的作用。
相似文献
1
Immunogenicity, safety and tolerability of intradermal influenza vaccines.皮内流感疫苗的免疫原性、安全性和耐受性。
Hum Vaccin Immunother. 2018 Mar 4;14(3):565-570. doi: 10.1080/21645515.2017.1328332. Epub 2017 Jul 6.
2
Dose sparing with intradermal injection of influenza vaccine.皮内注射流感疫苗的剂量节省
N Engl J Med. 2004 Nov 25;351(22):2295-301. doi: 10.1056/NEJMoa043540. Epub 2004 Nov 3.
3
Head-to-head comparison of an intradermal and a virosome influenza vaccine in patients over the age of 60: evaluation of immunogenicity, cross-protection, safety and tolerability.60岁以上患者皮内注射流感疫苗与病毒体流感疫苗的直接比较：免疫原性、交叉保护、安全性及耐受性评估
Hum Vaccin Immunother. 2013 Mar;9(3):591-8. doi: 10.4161/hv.23240. Epub 2013 Jan 7.
4
Comparison of the immunogenicity and safety of the conventional subunit, MF59-adjuvanted, and intradermal influenza vaccines in the elderly.老年人中传统亚单位疫苗、MF59佐剂疫苗和皮内注射流感疫苗的免疫原性和安全性比较。
Clin Vaccine Immunol. 2014 Jul;21(7):989-96. doi: 10.1128/CVI.00615-13. Epub 2014 May 14.
5
Immunogenicity and Safety of Reduced-Dose Intradermal vs Intramuscular Influenza Vaccines: A Systematic Review and Meta-analysis.低剂量皮内注射与肌内注射流感疫苗的免疫原性和安全性：一项系统评价与荟萃分析
JAMA Netw Open. 2021 Feb 1;4(2):e2035693. doi: 10.1001/jamanetworkopen.2020.35693.
6
Safety and immunogenicity of influenza vaccine among HIV-infected adults: Conventional vaccine vs. intradermal vaccine.HIV 感染成人中流感疫苗的安全性和免疫原性：传统疫苗与皮内疫苗对比
Hum Vaccin Immunother. 2016;12(2):478-84. doi: 10.1080/21645515.2015.1076599.
7
Safety and immunogenicity of high-dose quadrivalent influenza vaccine in adults ≥65 years of age: A phase 3 randomized clinical trial.≥65 岁老年人中高剂量四价流感疫苗的安全性和免疫原性：一项 3 期随机临床试验。
Vaccine. 2019 Sep 16;37(39):5825-5834. doi: 10.1016/j.vaccine.2019.08.016. Epub 2019 Aug 17.
8
Immunogenicity, large scale safety and lot consistency of an intradermal influenza vaccine in adults aged 18-60 years: Randomized, controlled, phase III trial.18至60岁成年人皮内注射流感疫苗的免疫原性、大规模安全性及批次一致性：随机对照III期试验
Hum Vaccin. 2010 Apr;6(4):346-54. doi: 10.4161/hv.6.4.10961. Epub 2010 Apr 15.
9
Immunogenicity and safety of the 2015 Southern Hemisphere formulation of a split-virion inactivated quadrivalent vaccine.2015 年南半球配方的四价流感病毒裂解疫苗的免疫原性和安全性。
Hum Vaccin Immunother. 2018 Mar 4;14(3):593-595. doi: 10.1080/21645515.2017.1377378. Epub 2017 Oct 30.
10
A phase 1, open-label, randomized study to compare the immunogenicity and safety of different administration routes and doses of virosomal influenza vaccine in elderly.一项1期、开放标签、随机研究，旨在比较不同给药途径和剂量的病毒体流感疫苗在老年人中的免疫原性和安全性。
Vaccine. 2016 Oct 17;34(44):5262-5272. doi: 10.1016/j.vaccine.2016.09.008. Epub 2016 Sep 22.
引用本文的文献
1
Molecular ingredients of an immunogen for long-lasting IgG.用于产生持久IgG的免疫原的分子成分。
Front Immunol. 2025 Aug 19;16:1639371. doi: 10.3389/fimmu.2025.1639371. eCollection 2025.
2
Unconjugated Multi-Epitope Peptides Adjuvanted with ALFQ Induce Durable and Broadly Reactive Antibodies to Human and Avian Influenza Viruses.与ALFQ佐剂结合的未偶联多表位肽可诱导产生针对人类和禽流感病毒的持久且广泛反应性的抗体。
Vaccines (Basel). 2023 Sep 8;11(9):1468. doi: 10.3390/vaccines11091468.
3
Exploiting Unique Features of Microneedles to Modulate Immunity.利用微针的独特特性来调节免疫。
Adv Mater. 2023 Dec;35(52):e2302410. doi: 10.1002/adma.202302410. Epub 2023 Nov 5.
4
Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity.皮内注射的可控自我复制RNA疫苗主要引发细胞免疫。
iScience. 2023 Mar 5;26(4):106335. doi: 10.1016/j.isci.2023.106335. eCollection 2023 Apr 21.
5
Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic?皮内接种疫苗：对抗新冠疫情的潜在工具？
Risk Manag Healthc Policy. 2021 May 20;14:2079-2087. doi: 10.2147/RMHP.S309707. eCollection 2021.
6
Immunogenicity and Safety of Reduced-Dose Intradermal vs Intramuscular Influenza Vaccines: A Systematic Review and Meta-analysis.低剂量皮内注射与肌内注射流感疫苗的免疫原性和安全性：一项系统评价与荟萃分析
JAMA Netw Open. 2021 Feb 1;4(2):e2035693. doi: 10.1001/jamanetworkopen.2020.35693.
7
Designing the next-generation therapeutic vaccines to cure chronic hepatitis B: focus on antigen presentation, vaccine properties and effect measures.设计用于治愈慢性乙型肝炎的下一代治疗性疫苗：聚焦抗原呈递、疫苗特性及疗效评估指标
Clin Transl Immunology. 2021 Jan 15;10(1):e1232. doi: 10.1002/cti2.1232. eCollection 2021.
8
Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma.激光辅助经皮免疫治疗用低变应原β-葡聚糖糖基化结合物抑制变应性哮喘小鼠模型中的肺部炎症并避免局部副作用。
Allergy. 2021 Jan;76(1):210-222. doi: 10.1111/all.14481. Epub 2020 Jul 16.
9
The 3Ds in virus-like particle based-vaccines: "Design, Delivery and Dynamics".基于病毒样颗粒疫苗的 3D 策略：“设计、传递和动力学”。
Immunol Rev. 2020 Jul;296(1):155-168. doi: 10.1111/imr.12863. Epub 2020 May 30.
10
Vaccines to Prevent Infectious Diseases in the Older Population: Immunological Challenges and Future Perspectives.预防老年人感染性疾病的疫苗：免疫挑战与未来展望。
Front Immunol. 2020 Apr 23;11:717. doi: 10.3389/fimmu.2020.00717. eCollection 2020.
本文引用的文献
1
A phase 1, open-label, randomized study to compare the immunogenicity and safety of different administration routes and doses of virosomal influenza vaccine in elderly.一项1期、开放标签、随机研究，旨在比较不同给药途径和剂量的病毒体流感疫苗在老年人中的免疫原性和安全性。
Vaccine. 2016 Oct 17;34(44):5262-5272. doi: 10.1016/j.vaccine.2016.09.008. Epub 2016 Sep 22.
2
Fluzone® intra-dermal (Intanza®/Istivac® Intra-dermal): An updated overview.流感病毒裂解疫苗（安尔来福/依维卡皮内注射剂）：最新概述
Hum Vaccin Immunother. 2016 Oct 2;12(10):2616-2627. doi: 10.1080/21645515.2016.1187343. Epub 2016 May 31.
3
Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial.皮内接种三价流感疫苗前外用咪喹莫特预防异源非疫苗和抗原漂移病毒：一项单中心、双盲、随机、对照 2b/3 期试验。
Lancet Infect Dis. 2016 Feb;16(2):209-18. doi: 10.1016/S1473-3099(15)00354-0. Epub 2015 Nov 9.
4
Differences in efficiency, satisfaction and adverse events between self-administered intradermal and nurse-administered intramuscular influenza vaccines in hospital workers.医院工作人员自行接种皮内流感疫苗与护士接种肌内流感疫苗在效率、满意度及不良事件方面的差异。
Vaccine. 2015 Nov 27;33(48):6635-40. doi: 10.1016/j.vaccine.2015.10.095. Epub 2015 Oct 31.
5
Immunogenicity and safety of intradermal influenza vaccine in immunocompromized patients: a meta-analysis of randomized controlled trials.免疫功能低下患者皮内注射流感疫苗的免疫原性和安全性：随机对照试验的荟萃分析
BMC Infect Dis. 2015 Oct 14;15:427. doi: 10.1186/s12879-015-1161-z.
6
Immunogenicity and Safety of Intradermal Influenza Vaccine in the Elderly: A Meta-Analysis of Randomized Controlled Trials.老年人皮内注射流感疫苗的免疫原性和安全性：随机对照试验的荟萃分析
Drugs Aging. 2015 Oct;32(10):857-69. doi: 10.1007/s40266-015-0303-8.
7
Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future.使用新型微针装置MicronJet600进行皮内接种：过去、现在与未来。
Hum Vaccin Immunother. 2015;11(4):991-7. doi: 10.1080/21645515.2015.1010871.
8
Immunogenicity of intramuscular MF59-adjuvanted and intradermal administered influenza enhanced vaccines in subjects aged over 60: A literature review.60岁以上人群中肌肉注射含MF59佐剂及皮内注射流感增强疫苗的免疫原性：一项文献综述
Hum Vaccin Immunother. 2015;11(3):553-63. doi: 10.1080/21645515.2015.1011562.
9
Immunogenicity of intradermal trivalent influenza vaccine with topical imiquimod: a double blind randomized controlled trial.皮内接种三价流感疫苗联合咪喹莫特治疗的免疫原性：一项双盲随机对照试验。
Clin Infect Dis. 2014 Nov 1;59(9):1246-55. doi: 10.1093/cid/ciu582. Epub 2014 Jul 21.
10
Immunogenicity and safety of intradermal trivalent influenza vaccination in nursing home older adults: a randomized controlled trial.养老院老年人皮内注射三价流感疫苗的免疫原性和安全性：一项随机对照试验。
J Am Med Dir Assoc. 2014 Aug;15(8):607.e5-12. doi: 10.1016/j.jamda.2014.05.002. Epub 2014 Jun 21.
Zotero 插件