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本文引用的文献

1
A phase 1, open-label, randomized study to compare the immunogenicity and safety of different administration routes and doses of virosomal influenza vaccine in elderly.一项1期、开放标签、随机研究，旨在比较不同给药途径和剂量的病毒体流感疫苗在老年人中的免疫原性和安全性。
Vaccine. 2016 Oct 17;34(44):5262-5272. doi: 10.1016/j.vaccine.2016.09.008. Epub 2016 Sep 22.
2
Fluzone® intra-dermal (Intanza®/Istivac® Intra-dermal): An updated overview.流感病毒裂解疫苗（安尔来福/依维卡皮内注射剂）：最新概述
Hum Vaccin Immunother. 2016 Oct 2;12(10):2616-2627. doi: 10.1080/21645515.2016.1187343. Epub 2016 May 31.
3
Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial.皮内接种三价流感疫苗前外用咪喹莫特预防异源非疫苗和抗原漂移病毒：一项单中心、双盲、随机、对照 2b/3 期试验。
Lancet Infect Dis. 2016 Feb;16(2):209-18. doi: 10.1016/S1473-3099(15)00354-0. Epub 2015 Nov 9.
4
Differences in efficiency, satisfaction and adverse events between self-administered intradermal and nurse-administered intramuscular influenza vaccines in hospital workers.医院工作人员自行接种皮内流感疫苗与护士接种肌内流感疫苗在效率、满意度及不良事件方面的差异。
Vaccine. 2015 Nov 27;33(48):6635-40. doi: 10.1016/j.vaccine.2015.10.095. Epub 2015 Oct 31.
5
Immunogenicity and safety of intradermal influenza vaccine in immunocompromized patients: a meta-analysis of randomized controlled trials.免疫功能低下患者皮内注射流感疫苗的免疫原性和安全性：随机对照试验的荟萃分析
BMC Infect Dis. 2015 Oct 14;15:427. doi: 10.1186/s12879-015-1161-z.
6
Immunogenicity and Safety of Intradermal Influenza Vaccine in the Elderly: A Meta-Analysis of Randomized Controlled Trials.老年人皮内注射流感疫苗的免疫原性和安全性：随机对照试验的荟萃分析
Drugs Aging. 2015 Oct;32(10):857-69. doi: 10.1007/s40266-015-0303-8.
7
Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future.使用新型微针装置MicronJet600进行皮内接种：过去、现在与未来。
Hum Vaccin Immunother. 2015;11(4):991-7. doi: 10.1080/21645515.2015.1010871.
8
Immunogenicity of intramuscular MF59-adjuvanted and intradermal administered influenza enhanced vaccines in subjects aged over 60: A literature review.60岁以上人群中肌肉注射含MF59佐剂及皮内注射流感增强疫苗的免疫原性：一项文献综述
Hum Vaccin Immunother. 2015;11(3):553-63. doi: 10.1080/21645515.2015.1011562.
9
Immunogenicity of intradermal trivalent influenza vaccine with topical imiquimod: a double blind randomized controlled trial.皮内接种三价流感疫苗联合咪喹莫特治疗的免疫原性：一项双盲随机对照试验。
Clin Infect Dis. 2014 Nov 1;59(9):1246-55. doi: 10.1093/cid/ciu582. Epub 2014 Jul 21.
10
Immunogenicity and safety of intradermal trivalent influenza vaccination in nursing home older adults: a randomized controlled trial.养老院老年人皮内注射三价流感疫苗的免疫原性和安全性：一项随机对照试验。
J Am Med Dir Assoc. 2014 Aug;15(8):607.e5-12. doi: 10.1016/j.jamda.2014.05.002. Epub 2014 Jun 21.

皮内流感疫苗的免疫原性、安全性和耐受性。

Immunogenicity, safety and tolerability of intradermal influenza vaccines.

机构信息

a Department of Medicine, the University of Hong Kong, Queen Mary Hospital , Hong Kong, Hong Kong Special Administrative Region , China.

b Carol Yu Centre for Infection and Division of Infectious Disease, State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology , the University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong Special Administrative Region , China.

出版信息

Hum Vaccin Immunother. 2018 Mar 4;14(3):565-570. doi: 10.1080/21645515.2017.1328332. Epub 2017 Jul 6.

DOI:10.1080/21645515.2017.1328332
PMID:28604266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5861844/
Abstract

Intradermal influenza vaccination has been studied for more than 80 y. The revived interest in this strategy of vaccination is a result of the innovative technologies in needle design allowing more precise injection and making the device easier to use. Furthermore, clinical trials on these novel devices have demonstrated significant dose sparing effects, improved immunogenicity and very few adverse effects. This review compares intradermal vaccination with various devices with subcutaneous and intramuscular vaccination. We also discussed the role of topical adjuvant before intradermal vaccination.

摘要

皮内流感疫苗接种的研究已经超过 80 年。人们对这种疫苗接种策略重新产生兴趣，是因为在针具设计方面的创新技术使得注射更加精确，操作更加简便。此外，这些新型器械的临床试验表明，皮内接种具有显著的节省剂量、提高免疫原性和极少不良反应的效果。本文比较了各种皮内接种器械与皮下和肌肉接种的效果。我们还讨论了皮内接种前局部应用佐剂的作用。