Coleman Brenda L, McNeil Shelly A, Langley Joanne M, Halperin Scott A, McGeer Allison J
Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada; University of Toronto, 155 College Street, Toronto, ON, Canada.
Canadian Center for Vaccinology, Dalhousie University, 6299 South Street, Halifax, NS, Canada; QE II Health Sciences Centre, Nova Scotia Health Authority, 1276 South Park Street, Halifax, NS, Canada.
Vaccine. 2015 Nov 27;33(48):6635-40. doi: 10.1016/j.vaccine.2015.10.095. Epub 2015 Oct 31.
Vaccinating healthcare workers against influenza takes tens of thousands of hours of work annually. This study was undertaken to determine the acceptability, success rate, and time to vaccinate healthcare workers in nurse-led groups that self-vaccinated with intradermal influenza vaccine compared with nurse-administered intramuscular vaccine.
Volunteer hospital workers were randomly assigned to groups that either self-administered intradermal influenza vaccine (Intanza(®)) in a nurse-led group or received nurse-administered intramuscular vaccine (Vaxigrip(®)). Research assistants timed vaccination procedures; pre- and post-injection questionnaires assessed acceptability and reactogenicity.
810 adults, 21-69 years of age, from two study sites were vaccinated: 401 self-administered the intradermal vaccine while 409 received their intramuscular vaccine from a nurse. Of those who self-administered for the first time, 98.5% were successful on their first attempt with an additional 1.5% on their second attempt. Acceptability was high: 96% were very or somewhat certain that they administered the vaccine correctly, 83% would choose intradermal influenza vaccine again and of those, 75% would choose self-administration again, if given the choice. It took 51.3-72.6s per person for the nurses to guide the groups through the self-administration process, which was significantly less time than it took to individually administer the intramuscular vaccines (93.6s).
Self-administration of intradermal influenza vaccine by people working in healthcare settings is a possible alternative to nurse administered vaccinations, with nurse-led group sessions a good way of teaching the technique while being available to respond to unanticipated problems (NCT01665807).
每年为医护人员接种流感疫苗需要耗费数万小时的工作时间。本研究旨在确定由护士指导的小组中，医护人员自行接种皮内流感疫苗与由护士接种肌内注射疫苗相比的可接受性、成功率及接种时间。
志愿参与的医院工作人员被随机分为两组，一组在护士指导下自行接种皮内流感疫苗（Intanza(®)），另一组接受护士接种的肌内注射疫苗（Vaxigrip(®)）。研究助手记录接种程序的时间；注射前后的问卷评估可接受性和反应原性。
来自两个研究地点的810名年龄在21至69岁的成年人接种了疫苗：401人自行接种皮内疫苗，409人由护士接种肌内疫苗。首次自行接种的人中，98.5%首次尝试成功，另有1.5%在第二次尝试时成功。可接受性较高：96%的人非常确定或有些确定自己正确接种了疫苗，83%的人会再次选择皮内流感疫苗，其中75%的人如果可以选择，会再次选择自行接种。护士指导小组进行自行接种过程，每人耗时51.3 - 72.6秒，这明显少于单独接种肌内疫苗所需的时间（93.6秒）。
医疗机构工作人员自行接种皮内流感疫苗是护士接种疫苗的一种可行替代方法，由护士指导的小组会议是教授该技术的好方法，同时可随时应对意外问题（NCT01665807）。
