Escobar Beatriz, Montenegro Iván, Villena Joan, Werner Enrique, Godoy Patricio, Olguín Yusser, Madrid Alejandro
Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile.
Escuela de Obstetricia y Puericultura, Facultad de medicina, Campus de la Salud, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile.
Molecules. 2017 Jun 10;22(6):968. doi: 10.3390/molecules22060968.
An efficient synthesis of a series of 4'-oxyalkyl-isocordoin analogues (-) is reported for the first time. Their structures were confirmed by ¹H-NMR, C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: and . The entire series of isocordoin derivatives (except compound ) showed high inhibitory activity against these oomycete strains. Among them, compound exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4'-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.
首次报道了一系列4'-氧烷基异柯多因类似物（-）的高效合成方法。其结构通过¹H-NMR、C-NMR和HRMS得到确证。通过针对两种选定的致病卵菌菌株： 和 的菌丝体和孢子抑制试验评估了它们的抗卵菌活性。整个异柯多因衍生物系列（化合物 除外）对这些卵菌菌株表现出高抑制活性。其中，化合物 表现出强活性，最小抑菌浓度（MIC）和最小杀卵菌浓度（MOC）值分别为50 µg/mL和75 µg/mL。结果表明，异柯多因的4'-氧烷基化类似物可能是潜在的抗卵菌剂。
