精油和黄樟素衍生物的化学分析及生物活性对卵菌鱼类病原菌的抑制作用

Chemical Analysis and Bioactivity of Essential Oil of and Safrole Derivatives against Oomycete Fish Pathogens.

机构信息

Laboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Departamento de Ciencias y Geografía, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile.

Facultad de Farmacia, Escuela de Química y Farmacia, Universidad de Valparaíso, Av. Gran Bretaña 1093, Valparaíso 2340000, Chile.

出版信息

Molecules. 2021 Oct 29;26(21):6551. doi: 10.3390/molecules26216551.

DOI:10.3390/molecules26216551

PMID:34770960

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8588113/

Abstract

In this study, the essential oil (EO) from was analyzed by GC/MS and safrole () was identified as the major metabolite , was subjected to direct reactions on the oxygenated groups in the aromatic ring and in the side chain, and eight compounds ( to ) were obtained by the process. EO and compounds - were subjected to biological assays on 24 strains of the genus , specifically of the species 12 and 12 . EO showed a significant effect against strains. Compound presents the highest activity against two resistant strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 25 to 100 and 75 to 125 µg/mL, respectively. The results show that compound exhibited superior activities compared to the commercial controls bronopol and azoxystrobin used to combat these pathogens.

摘要

在这项研究中，通过 GC/MS 对进行了精油（EO）分析，鉴定出主要代谢物为黄樟素（）。将黄樟素（）直接作用于芳环和侧链上的含氧基团，通过该过程得到了 8 种化合物（至）。对 24 株属细菌，特别是 12 种和 12 种的 12 个菌株进行了 EO 和化合物 - 的生物测定。EO 对株具有显著的抑制作用。化合物对两种耐药菌株表现出最高的活性，最低抑菌浓度（MIC）和最低杀真菌浓度（MOC）值分别为 25 至 100 和 75 至 125 µg/mL。结果表明，与用于对抗这些病原体的商业对照物溴硝醇和唑菌胺酯相比，化合物表现出更高的活性。