van der Ende M Yldau, Siland Joylene E, Snieder Harold, van der Harst Pim, Rienstra Michiel
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Clin Cardiol. 2017 Oct;40(10):865-872. doi: 10.1002/clc.22737. Epub 2017 Jun 12.
Our aim is to present average values and prevalence of electrocardiographic (ECG) abnormalities among the general Dutch population in the LifeLines Cohort.
The ECG values previously studied in the Caucasian population of smaller cohorts will be confirmed with ECG data from LifeLines.
ECG data of 152 180 individuals age 18 to 93 years were available. Individuals with cardiovascular risk factors were excluded to analyze the healthy population. Average values of the ECG for the healthy population were presented as means with 95% and 99% confidence intervals and as medians with first and 99th percentiles.
Median heart rate was highest in the youngest and oldest individuals of the healthy population. Median duration of P wave, PQ interval, and QRS duration were longer in males compared with females. In contrast, median QT interval corrected for heart rate was higher in females. In general, the above-mentioned parameters increased with age. The prevalences of ECG abnormalities adjusted for the Dutch population were 0.9% for atrial fibrillation or flutter, 1.4% for premature atrial complexes, 0.5% for myocardial infarction, 2.1% for ventricular premature complexes, 1.0% for left ventricular hypertrophy, 8.1% for P-R interval >200 ms, and 0.8% for bundle branch block.
Our study provides an overview of average values and ECG abnormalities and confirms data of previous smaller studies. In addition, we evaluate the age- and sex-dependent normal limits of the P wave and QRS duration and confirm in detail the frontal plane QRS-T angle on the ECG.
我们的目的是呈现荷兰生命线队列研究中普通人群心电图（ECG）异常的平均值和患病率。
先前在较小队列的白种人群中研究的心电图值将通过生命线队列的心电图数据得到证实。
获取了152180名年龄在18至93岁之间个体的心电图数据。排除有心血管危险因素的个体以分析健康人群。健康人群心电图的平均值以带有95%和99%置信区间的均值以及带有第1百分位数和第99百分位数的中位数形式呈现。
健康人群中最年轻和最年长个体的心率中位数最高。男性的P波持续时间、PQ间期和QRS波群持续时间的中位数比女性长。相比之下，经心率校正后的QT间期中位数在女性中更高。一般来说，上述参数随年龄增加。根据荷兰人群调整后的心电图异常患病率分别为：房颤或房扑0.9%，房性早搏1.4%，心肌梗死0.5%，室性早搏2.1%，左心室肥厚1.0%，P-R间期>200 ms为8.1%，束支传导阻滞0.8%。
我们的研究提供了平均值和心电图异常的概述，并证实了先前较小规模研究的数据。此外，我们评估了P波和QRS波群持续时间的年龄和性别依赖性正常范围，并详细确认了心电图额面QRS-T夹角。
