Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23219, USA.
Department of Microbiology and Immunology, VCU School of Medicine, 1101 East Marshall Street, Richmond, VA, 23298, USA.
Macromol Biosci. 2017 Sep;17(9). doi: 10.1002/mabi.201700090. Epub 2017 Jun 12.
A preliminary study is reported for a polycation antimicrobial peptide (AMP) mimic against Propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. Antibiotics are commonly used against P. acnes but buildup of resistance is well-known. Worse, antibiotic regimens build up resistance for more sensitive bacteria such as Staphylococcus epidermidis. The polycation AMP mimic C12-50, 1, is chosen for the present study as it has been previously shown to have high antimicrobial effectiveness. This study reports that C12-50 is active against P. acnes (strain ATCC 6919) with a minimum inhibitory concentration (MIC) of 6.3 µg mL . To monitor resistance build-up ten passages are conducted with C12-50 against P. acnes. The MIC remains constant with no resistance buildup. Parallel studies with erythromycin confirm previously reported resistance buildup. The results point to a promising pathway to applications for polycation AMP mimics against P. acnes.
本文报道了一种针对痤疮丙酸杆菌（与寻常痤疮有关的细菌）的聚阳离子抗菌肽（AMP）模拟物的初步研究。抗生素常用于治疗痤疮丙酸杆菌，但众所周知，这种细菌会产生耐药性。更糟糕的是，抗生素疗法会使表皮葡萄球菌等更敏感的细菌产生耐药性。本研究选择聚阳离子 AMP 模拟物 C12-50,1 进行研究，因为它之前已被证明具有很高的抗菌效果。本研究报告称，C12-50 对痤疮丙酸杆菌（ATCC 6919 株）具有活性，最小抑菌浓度（MIC）为 6.3 µg mL 。为了监测耐药性的建立，对 C12-50 进行了 10 次针对痤疮丙酸杆菌的传代实验。MIC 保持不变，没有耐药性的建立。与红霉素的平行研究证实了之前报道的耐药性的建立。这些结果表明，聚阳离子 AMP 模拟物在治疗痤疮丙酸杆菌方面具有广阔的应用前景。
