Nishijima S, Akamatsu H, Akamatsu M, Kurokawa I, Asada Y
Department of Dermatology, Kansai Medical University, Osaka, Japan.
J Dermatol. 1994 Mar;21(3):166-71. doi: 10.1111/j.1346-8138.1994.tb01715.x.
We studied the susceptibility of antimicrobial agents to Propionibacterium acnes (P. acnes) and Staphylococcus epidermidis (S. epidermidis) isolated from acne patients. We measured the minimum inhibitory concentrations (MICs) of the following five drugs: roxithromycin (RXM), erythromycin (EM), clindamycin (CLDM), minocycline (MINO) and ofloxacin (OFLX), which are frequently used to treat acne and skin infections. We found many resistant strains of S. epidermidis and some resistant strains of P. acnes. There was a correlation between the resistance of S. epidermidis and the former therapy for acne, but no distinct correlation between the resistance of P. acnes and the former therapy for acne.
我们研究了抗菌药物对从痤疮患者中分离出的痤疮丙酸杆菌（P. acnes）和表皮葡萄球菌（S. epidermidis）的敏感性。我们测定了以下五种常用于治疗痤疮和皮肤感染的药物的最低抑菌浓度（MIC）：罗红霉素（RXM）、红霉素（EM）、克林霉素（CLDM）、米诺环素（MINO）和氧氟沙星（OFLX）。我们发现了许多表皮葡萄球菌耐药菌株和一些痤疮丙酸杆菌耐药菌株。表皮葡萄球菌的耐药性与痤疮的既往治疗之间存在相关性，但痤疮丙酸杆菌的耐药性与痤疮的既往治疗之间没有明显的相关性。
