Slizgi G R, Ludens J H
Life Sci. 1985 Jun 10;36(23):2189-93. doi: 10.1016/0024-3205(85)90328-5.
Multiple opioid binding sites have been documented in brain tissue. In this study we report on the presence of binding sites for the opioid ethylketocyclazocine (EKC) in a membrane fraction of rat kidney. Binding appeared to be selective in that opioids varied markedly in their capacities to displace 3H-EKC. Correlating with the capacity of an opioid to displace 3H-EKC was the ability to produce diuresis. Although our studies cannot assign a particular physiological or pharmacological role for the renal EKC binding sites, binding studies of this nature may, nonetheless, be a means by which diuretic activity of opioids can be predicted.
在脑组织中已证实存在多个阿片样物质结合位点。在本研究中，我们报告了在大鼠肾脏膜组分中存在阿片样物质乙基酮环唑辛（EKC）的结合位点。结合似乎具有选择性，因为不同阿片样物质置换³H-EKC的能力差异显著。阿片样物质置换³H-EKC的能力与其产生利尿作用的能力相关。虽然我们的研究无法确定肾脏EKC结合位点的特定生理或药理作用，但这种性质的结合研究可能是预测阿片样物质利尿活性的一种手段。
