Gao Shaowei, He Qiulan
Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Front Pharmacol. 2024 Jul 25;15:1421248. doi: 10.3389/fphar.2024.1421248. eCollection 2024.
Renal dysfunction, including acute renal failure (ARF) and chronic kidney disease (CKD), continues to present significant health challenges, with renal ischemia-reperfusion injury (IRI) being a pivotal factor in their development and progression. This condition, notably impacting kidney transplantation outcomes, underscores the urgent need for innovative therapeutic interventions. The role of opioid agonists in this context, however, remains a subject of considerable debate. Current reviews tend to offer limited perspectives, focusing predominantly on either the protective or detrimental effects of opioids in isolation. Our review addresses this gap through a thorough and comprehensive evaluation of the existing literature, providing a balanced examination of the dualistic nature of opioids' influence on renal health. We delve into both the nephroprotective and nephrotoxic aspects of opioids, dissecting the complex interactions and paradoxical effects that embody the "two sides of the same coin" phenomenon. This comprehensive analysis is vital for understanding the intricate roles of opioids in renal pathophysiology, potentially informing the development of novel therapeutic strategies for preventing or treating hypoxic kidney injury.
肾功能障碍，包括急性肾衰竭（ARF）和慢性肾脏病（CKD），仍然是重大的健康挑战，肾缺血再灌注损伤（IRI）是其发生和发展的关键因素。这种情况尤其影响肾移植结果，凸显了对创新治疗干预措施的迫切需求。然而，阿片类激动剂在这方面的作用仍然是一个备受争议的话题。目前的综述往往提供有限的观点，主要侧重于阿片类药物单独的保护或有害作用。我们的综述通过对现有文献进行全面而深入的评估来弥补这一差距，对阿片类药物对肾脏健康影响的二元性进行平衡审视。我们深入探讨阿片类药物的肾保护和肾毒性方面，剖析体现“同一枚硬币的两面”现象的复杂相互作用和矛盾效应。这种全面分析对于理解阿片类药物在肾脏病理生理学中的复杂作用至关重要，可能为预防或治疗缺氧性肾损伤的新型治疗策略的开发提供依据。
