慢性肾衰竭患者的甲状腺体积及甲状腺激素血清浓度

Thyroid gland volume and serum concentrations of thyroid hormones in chronic renal failure.

作者信息

Hegedüs L, Andersen J R, Poulsen L R, Perrild H, Holm B, Gundtoft E, Hansen J M

出版信息

Nephron. 1985;40(2):171-4. doi: 10.1159/000183455.

Abstract

Thyroid gland volume, ultrasonically determined, and thyroid function were investigated in 40 patients with chronic renal failure (33 of these on hemodialysis) and 40 sex-, age- and weight-matched healthy controls. None had thyroid autoantibodies or a clinically detectable goiter. The median thyroid gland volume was significantly elevated in the uremic patients: 24 ml (range 8-43 ml) compared with the healthy controls 17 ml (range 10-22 ml) (p less than 0.005). The serum concentrations of thyroxine (T4), triiodothyronine (T3), free thyroxine index (FT4I) and free triiodothyronine index (FT3I) were significantly decreased in uremic subjects compared with the controls. The serum concentration of thyrotropin did not differ significantly between patients and controls. None of the thyroid function variables correlated with thyroid gland volume. In conclusion, thyroid gland volume was increased in patients with chronic renal failure. The alterations in thyroid hormone concentrations could, however, not explain this finding.

摘要

对40例慢性肾衰竭患者（其中33例接受血液透析）以及40名性别、年龄和体重匹配的健康对照者进行了甲状腺体积（通过超声测定）和甲状腺功能的研究。所有人均无甲状腺自身抗体或临床上可检测到的甲状腺肿。尿毒症患者的甲状腺体积中位数显著升高：为24毫升（范围8 - 43毫升），而健康对照者为17毫升（范围10 - 22毫升）（p < 0.005）。与对照组相比，尿毒症患者血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）、游离甲状腺素指数（FT4I）和游离三碘甲状腺原氨酸指数（FT3I）的浓度显著降低。患者和对照者之间促甲状腺素的血清浓度无显著差异。甲状腺功能变量与甲状腺体积均无相关性。总之，慢性肾衰竭患者的甲状腺体积增大。然而，甲状腺激素浓度的改变无法解释这一发现。