Bellos Ioannis, Papantoniou Nikolaos, Pergialiotis Vasilios
a Third Department of Obstetrics and Gynecology , Attikon University Hospital, National and Kapodistrian University of Athens , Athens , Greece.
J Matern Fetal Neonatal Med. 2018 Sep;31(17):2342-2348. doi: 10.1080/14767058.2017.1340449. Epub 2017 Jun 28.
To evaluate the differences in serum ceruloplasmin levels between patients with preeclampsia and healthy controls.
We searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017), and Google Scholar (2004-2017) databases. Meta-analysis was performed with the RevMan 5.3 software.
Fifteen studies were finally included in the present review, with a total number of 1927 women. Maternal serum ceruloplasmin concentration was significantly higher in preeclamptic than in the healthy pregnant women (mean differences (MD): 12.57 mg/dl, 95% CI: [8.81, 16.33]). Ceruloplasmin levels were significantly higher both in mild (MD: 13.8 mg/dl, 95% CI: [2.64, 23.53]) and severe (MD: 21.84 mg/dl, 95% CI: [0.97, 42.71]) preeclampsia, when compared to the control group. The severity of the disease did not significantly affect the levels of the protein (MD: -9.34 mg/dl, 95% CI: [-20.93, 2.26]).
Serum ceruloplasmin may be a useful screening and follow-up tool for the evaluation of pregnant women with an indicative history of developing preeclampsia. Future studies are needed to evaluate the levels of this specific protein throughout the pregnancy course and provide data on its sensitivity and specificity by introducing cut-off values.
评估先兆子痫患者与健康对照者血清铜蓝蛋白水平的差异。
我们检索了Medline（1966 - 2017年）、Scopus（2004 - 2017年）、Clinicaltrials.gov（2008 - 2017年）、Cochrane对照试验中心注册库CENTRAL（1999 - 2017年）以及谷歌学术（2004 - 2017年）数据库。使用RevMan 5.3软件进行荟萃分析。
本综述最终纳入15项研究，共1927名女性。先兆子痫患者的母血血清铜蓝蛋白浓度显著高于健康孕妇（平均差异（MD）：12.57mg/dl，95%置信区间：[8.81, 16.33]）。与对照组相比，轻度（MD：13.8mg/dl，95%置信区间：[2.64, 23.53]）和重度（MD：21.84mg/dl，95%置信区间：[0.97, 42.71]）先兆子痫患者的铜蓝蛋白水平均显著升高。疾病严重程度对该蛋白水平无显著影响（MD： - 9.34mg/dl，95%置信区间：[-20.93, 2.26]）。
血清铜蓝蛋白可能是评估有先兆子痫发病指示性病史孕妇的有用筛查和随访工具。未来需要进行研究以评估整个孕期该特定蛋白的水平，并通过引入临界值提供其敏感性和特异性的数据。
