Li B, Ye J J, Zhang M F, Li D H
Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China.
Zhonghua Yan Ke Za Zhi. 2017 Jun 11;53(6):436-439. doi: 10.3760/cma.j.issn.0412-4081.2017.06.008.
To conclude the characteristics of fundus appearance and spectral domain optical coherence tomography(SD-OCT) findings of patients with acute Vogt-Koyanagi-Harada (VKH) disease. The clinical data of 17 patients (34 eyes) diagnosed of acute VKH in Peking Union Medical College Hospital from Jan. 2012 to Dec. 2014 were studied retrospectively.Examinations included visual acuity, slit lamp, fundus, color fundus pictures, FFA and SD-OCT. Eight men and 9 women were enrolled with mean age of (40.5±11.6) years old ranging from 26.0 to 62.0 years old. Vision acuity of their first consultations were as follows: 14 eyes (41.2%) were below 0.01-0.09, 17 eyes(50%) were among 0.1-0.3, 3 eyes (8.8%) were among 0.4-0.7. All patients were divided into 3 groups according to their fundus appearance: 14 eyes (41.2%) were optic disc swelling-type, 10 eyes (29.4%) were retinal detachment type and 10 eyes(29.4%)were mixed type. Subretinal fluid and serous retinal detachment appears in SD-OCT of all 34 eyes, with highly reflective signals in detached area. Other common characters were also noticeable, suh as RPE folds(19 eyes, 55.9%), subretinal septa (16 eyes, 47.1%) and internal limiting membrane(ILM) fluctuation (8 eyes, 23.5%). In addition, SD-OCT features were in accordance with multilobular dye pooling at late period of FFA. SD-OCT of acute VKH presents some typical features: subretinal fluid and serous retinal detachment, RPE folds, ILM fluctuation, and subretinal septa..
总结急性Vogt-小柳-原田（VKH）病患者的眼底表现及频域光学相干断层扫描（SD-OCT）结果的特征。回顾性研究2012年1月至2014年12月在北京协和医院确诊为急性VKH的17例患者（34只眼）的临床资料。检查包括视力、裂隙灯、眼底、彩色眼底照片、荧光素眼底血管造影（FFA）和SD-OCT。纳入8例男性和9例女性，平均年龄（40.5±11.6）岁，年龄范围为26.0至62.0岁。他们初诊时的视力情况如下：14只眼（41.2%）低于0.01 - 0.09，17只眼（50%）在0.1 - 0.3之间，3只眼（8.8%）在0.4 - 0.7之间。所有患者根据眼底表现分为3组：14只眼（41.2%）为视盘肿胀型，10只眼（29.4%）为视网膜脱离型，10只眼（29.4%）为混合型。34只眼中所有眼睛的SD-OCT均显示视网膜下液和浆液性视网膜脱离，脱离区域有高反射信号。其他常见特征也很明显，如视网膜色素上皮（RPE）皱褶（19只眼，55.9%）、视网膜下间隔（16只眼，47.1%）和内界膜（ILM）波动（8只眼，23.5%）。此外，SD-OCT特征与FFA晚期的多叶状染料渗漏相符。急性VKH的SD-OCT呈现一些典型特征：视网膜下液和浆液性视网膜脱离、RPE皱褶、ILM波动和视网膜下间隔。
