Vogt-小柳-原田病急性和慢性期的光学相干断层扫描
Optical coherence tomography in the acute and chronic phases of Vogt-Koyanagi-Harada disease.
作者信息
Parc Christine, Guenoun Jean-Marc, Dhote Robin, Brézin Antoine
机构信息
Department of Ophthalmology, Hôpital Cochin, Paris V University, France.
出版信息
Ocul Immunol Inflamm. 2005 Apr-Jun;13(2-3):225-7. doi: 10.1080/09273940490912416.
PURPOSE
To assess the potential of optical coherence tomography (OCT) in the diagnosis and monitoring of serous retinal detachment in Vogt-Koyanagi-Harada (VKH) disease and to describe OCT characteristics of subretinal sequelae of the disease.
METHODS
Six patients in the acute phase of VKH disease with serous retinal detachment were followed in our department from July 2001 to December 2003 using slit-lamp biomicroscopy, OCT, and fluorescein angiography.
RESULTS
OCT was effective in objectively quantifying the amount of serous retinal detachment present and then in following the resolution of subretinal fluid accumulation. Subretinal pigmented lesions on angiography corresponded with retinal pigment epithelium hypertrophy and fibrosis on OCT.
CONCLUSION
A beneficial effect of treatment was observed within days, paralleling the improvement in visual acuity. Retinal pigment epithelium hypertrophy and fibrosis in the chronic phase of the disease were analyzed with OCT for the first time.
目的
评估光学相干断层扫描（OCT）在伏格特-小柳-原田（VKH）病浆液性视网膜脱离诊断及监测中的潜力，并描述该病视网膜下后遗症的OCT特征。
方法
2001年7月至2003年12月，在我科对6例处于VKH病急性期且伴有浆液性视网膜脱离的患者进行了裂隙灯生物显微镜检查、OCT及荧光素血管造影随访。
结果
OCT能有效地客观量化存在的浆液性视网膜脱离量，进而追踪视网膜下液积聚的消退情况。血管造影上的视网膜下色素性病变与OCT上的视网膜色素上皮肥大及纤维化相对应。
结论
在数天内观察到治疗的有益效果，这与视力改善情况相符。首次用OCT分析了该病慢性期的视网膜色素上皮肥大及纤维化情况。
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