Fouilladieu J L, d'Enfert J, Zerbib M, Yeganeh N, Baudin F, Conseiller C
Presse Med. 1985 May 4;14(18):1009-12.
This report adds three cases to those previously published of paradoxical reactions to benzodiazepines. The clinical syndrome, more or less complete, is fairly stereotyped, with behavioural disorders, tendency to feelings of hostility and aggressiveness and total anterograde amnesia. Personal and environmental factors seem to play a prominent role in its development. The classical contra-indication of benzodiazepines following such reactions is discussed, and the hypothesis that mamillary-thalamic benzodiazepine receptors play a part in their genesis is envisaged.
本报告在此前已发表的苯二氮卓类药物矛盾反应病例基础上新增了三例。这种临床综合征或多或少较为完整,且相当刻板,表现为行为障碍、有敌意和攻击性倾向以及完全性顺行性遗忘。个人因素和环境因素在其发展过程中似乎起着重要作用。文中讨论了此类反应后苯二氮卓类药物的经典禁忌证,并设想乳头体 - 丘脑苯二氮卓受体在其发病机制中起作用。