Hall R C, Zisook S
Br J Clin Pharmacol. 1981;11 Suppl 1(Suppl 1):99S-104S. doi: 10.1111/j.1365-2125.1981.tb01844.x.
The overall incidence of paradoxical responses to the benzodiazepines is extremely small, but a few controlled studies have been carried out which define the population at risk. Such reactions tend to be idiosyncratic except possibly in patients with pre-rage personality, and do not seem to be associated with any predictable clinical indications.
苯二氮䓬类药物反常反应的总体发生率极低,但已经开展了一些对照研究来确定高危人群。除了可能在有暴发性人格的患者中,这类反应往往是特异质性的,而且似乎与任何可预测的临床指征无关。