Grabowska Anna I, Wilanowski Tomasz
Laboratory of Neuroplasticity, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland
Laboratory of Signal Transduction, Department of Cell Biology, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland.
Mol Cell Biol. 2017 Aug 11;37(17). doi: 10.1128/MCB.00110-17. Print 2017 Sep 1.
FOXN1 is a prodifferentiation transcription factor in the skin epithelium. Recently, it has also emerged as an important player in controlling the skin wound healing process, as it actively participates in reepithelialization and is thought to be responsible for scar formation. FOXN1 positivity is also a feature of pigmented keratinocytes, including nevi, and FOXN1 is an attribute of benign epithelial tumors. The lack of FOXN1 favors the skin regeneration process displayed by nude mice, pointing to FOXN1 as a switch between regeneration and reparative processes. The stem cell niche provides a functional source of cells after the loss of tissue following wounding. The involvement of prodifferentiation factors in the regulation of this pool of stem cells is suggested. However, the exact mechanism is still under question, and we speculate that the FOXN1 transcription factor is involved in this process. This review analyzes the pleiotropic effects of FOXN1 in the skin, its function in the tumorigenesis process, and its potential role in depletion of the stem cell niche after injury, as well as its suggested mechanistic role, acting in a cell-autonomous and a non-cell-autonomous manner during skin self-renewal.
FOXN1是皮肤上皮中的一种促分化转录因子。最近，它也成为控制皮肤伤口愈合过程的重要参与者，因为它积极参与再上皮化，并且被认为与瘢痕形成有关。FOXN1阳性也是色素沉着角质形成细胞（包括痣）的一个特征，并且FOXN1是良性上皮肿瘤的一个属性。缺乏FOXN1有利于裸鼠所表现出的皮肤再生过程，这表明FOXN1是再生和修复过程之间的一个开关。干细胞生态位在受伤后组织缺失后提供了细胞的功能来源。提示促分化因子参与了对这一干细胞池的调节。然而，确切机制仍存在疑问，并且我们推测FOXN1转录因子参与了这一过程。本综述分析了FOXN1在皮肤中的多效性作用、其在肿瘤发生过程中的功能、其在损伤后干细胞生态位耗竭中的潜在作用，以及其在皮肤自我更新过程中以细胞自主和非细胞自主方式发挥作用的推测机制作用。
