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Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA.对头孢克肟和头孢曲松敏感性降低的淋病奈瑟菌分离株：与penA、mtrR、porB1b和ponA基因多态性的关联
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Neisseria gonorrhoeae antimicrobial susceptibility in Barcelona: penA, ponA, mtrR, and porB mutations and NG-MAST sequence types associated with decreased susceptibility to cephalosporins.巴塞罗那淋病奈瑟菌的抗菌药物敏感性：penA、ponA、mtrR和porB基因突变以及与头孢菌素敏感性降低相关的NG-MAST序列类型
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Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone.淋病奈瑟菌分离株中 penA 突变与 mtrR、porB 和 ponA 突变共同导致对头孢克肟或头孢曲松的低敏感性。
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Drug-resistant Neisseria gonorrhoeae: latest developments.耐多药淋病奈瑟菌：最新进展
Eur J Clin Microbiol Infect Dis. 2017 Jul;36(7):1065-1071. doi: 10.1007/s10096-017-2931-x. Epub 2017 Feb 16.
2
Neisseria gonorrhoeae antimicrobial susceptibility in Barcelona: penA, ponA, mtrR, and porB mutations and NG-MAST sequence types associated with decreased susceptibility to cephalosporins.巴塞罗那淋病奈瑟菌的抗菌药物敏感性：penA、ponA、mtrR和porB基因突变以及与头孢菌素敏感性降低相关的NG-MAST序列类型
Eur J Clin Microbiol Infect Dis. 2016 Sep;35(9):1549-56. doi: 10.1007/s10096-016-2696-7. Epub 2016 Jun 2.
3
First nationwide study regarding ceftriaxone resistance and molecular epidemiology of Neisseria gonorrhoeae in China.中国关于淋病奈瑟菌对头孢曲松耐药性及分子流行病学的首次全国性研究。
J Antimicrob Chemother. 2016 Jan;71(1):92-9. doi: 10.1093/jac/dkv321. Epub 2015 Oct 15.
4
Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge.淋病的当前及未来抗菌治疗——不断快速演变的淋病奈瑟菌持续构成挑战。
BMC Infect Dis. 2015 Aug 21;15:364. doi: 10.1186/s12879-015-1029-2.
5
High Prevalence of Azithromycin-Resistant Neisseria gonorrhoeae Isolates With a Multidrug Resistance Phenotype in Fukuoka, Japan.日本福冈地区阿奇霉素耐药且具有多药耐药表型的淋病奈瑟菌分离株的高流行率
Sex Transm Dis. 2015 Jun;42(6):337-41. doi: 10.1097/OLQ.0000000000000279.
6
Azithromycin resistance and its mechanism in Neisseria gonorrhoeae strains in Hyogo, Japan.日本兵库县淋病奈瑟菌菌株中的阿奇霉素耐药性及其机制。
Antimicrob Agents Chemother. 2015 May;59(5):2695-9. doi: 10.1128/AAC.04320-14. Epub 2015 Feb 23.
7
Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.21世纪淋病奈瑟菌的抗菌药物耐药性：过去、演变及未来
Clin Microbiol Rev. 2014 Jul;27(3):587-613. doi: 10.1128/CMR.00010-14.
8
Antimicrobial resistance and molecular typing of Neisseria gonorrhoeae isolates in Kyoto and Osaka, Japan, 2010 to 2012: intensified surveillance after identification of the first strain (H041) with high-level ceftriaxone resistance.2010 至 2012 年日本京都和大阪地区淋病奈瑟菌分离株的耐药性和分子分型：首例高水平头孢曲松耐药菌株（H041）鉴定后的强化监测
Antimicrob Agents Chemother. 2013 Nov;57(11):5225-32. doi: 10.1128/AAC.01295-13. Epub 2013 Aug 12.
9
Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone.在欧洲淋球菌抗菌药物耐药监测项目中进行的分子流行病学分型显示，一种多重耐药克隆占据主导地位。
Euro Surveill. 2013 Jan 17;18(3):20358.
10
Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone.淋病奈瑟菌是否开启了无法治愈的淋病的未来时代？：对首例高水平头孢曲松耐药菌株的详细特征描述。
Antimicrob Agents Chemother. 2011 Jul;55(7):3538-45. doi: 10.1128/AAC.00325-11. Epub 2011 May 16.

, , , and Mutations and Molecular Epidemiological Typing of Neisseria gonorrhoeae with Decreased Susceptibility to Cephalosporins.

作者信息

Osawa Kayo, Shigemura Katsumi, Nukata Yukie, Kitagawa Koichi, Yamamichi Fukashi, Yoshida Hiroyuki, Shirakawa Toshiro, Arakawa Soichi, Fujisawa Masato

机构信息

Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan.

Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan

出版信息

Antimicrob Agents Chemother. 2017 Jul 25;61(8). doi: 10.1128/AAC.01174-17. Print 2017 Aug.

DOI:10.1128/AAC.01174-17
PMID:28607013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5527564/
Abstract
摘要