Gupta Priyanka, Mital Ritu, Kumar Bimlesh, Yadav Ajeet, Jain Mohit, Upadhyay Amit
Department of Pediatrics, LLRM Medical College, Meerut, UP, India. Correspondence to: Dr Amit Upadhyay, Head, Department of Pediatrics, LLRM Medical College, Meerut, Uttar Pradesh, India.
Indian Pediatr. 2017 Aug 15;54(8):629-634. doi: 10.1007/s13312-017-1123-1. Epub 2017 Jun 4.
To compare the physical growth outcomes, morbidity profile and mortality at an age of 12 months among late preterm (34 0/7to 36 6/7) neonates to term (37 0/7to 41 6/7) neonates.
Prospective cohort study.
A tertiary care center of Northern India during 2014-2015.
200 apparently healthy late preterms and term infants, followed up to 12 months of age.
Physical growth parameters, morbidity profile and mortality.
At mean age of 12 months, mean (SD) weight, length and head circumference of late preterms were 7.4 (0.8) kg, 69.2 (2.5) cm and 43.0 (1.1) cm, respectively; which were significantly lower than that of the full term infants [8.7 (1.6) kg, 72.2 (3.1) cm and 44.2 (1.1) cm] (P< 0.001). On univariate analysis, late preterm group was associated with higher odds (95% CI) of being underweight [5.6 (3.4, 5.5)], stunted [3.5 (2.1, 5.8)] and wasted [3.6 (1.9, 6.9)]. On multivariate analysis, only adjusted odds of late preterms becoming underweight by one year was significant [OR 4.1; 95% CI (1.6, 10.4)]. Feeding difficulties, jaundice and re-hospitalization rates were significantly higher in the late preterm group. The median (IQR) episodes per baby for late preterms as compared to terms for diarrhea [1.84 (0,3) vs 1.14 (0,2) (P <0.001)], and fever [1.33 (0,2) vs. 0.95 (0,2) (P = 0.01)] were higher.
Healthy late preterms are at significantly higher risk of being underweight in the first year of life, in addition to having significantly higher morbidity.
比较晚期早产儿（34⁰/₇至36⁶/₇周）与足月儿（37⁰/₇至41⁶/₇周）12月龄时的体格生长指标、发病情况和死亡率。
前瞻性队列研究。
2014 - 2015年印度北部的一家三级医疗中心。
200名外观健康的晚期早产儿和足月儿，随访至12月龄。
体格生长参数、发病情况和死亡率。
在12月龄时，晚期早产儿的平均（标准差）体重、身长和头围分别为7.4（0.8）kg、69.2（2.5）cm和43.0（1.1）cm；显著低于足月儿[8.7（1.6）kg、72.2（3.1）cm和44.2（1.1）cm]（P <0.001）。单因素分析显示，晚期早产儿组体重不足[比值比（95%置信区间）为5.6（3.4, 5.5）]、发育迟缓[3.5（2.1, 5.8）]和消瘦[3.6（1.9, 6.9）]的几率更高。多因素分析显示，仅晚期早产儿1岁时体重不足的校正比值比具有统计学意义[比值比4.1；95%置信区间（1.6, 10.4）]。晚期早产儿组的喂养困难、黄疸和再次住院率显著更高。晚期早产儿每例婴儿腹泻的中位数（四分位间距）发作次数[1.84（0,3）对比1.14（0,2）（P <0.001）]和发热发作次数[1.33（0,2）对比0.95（0,2）（P = 0.01）]高于足月儿。
健康的晚期早产儿在生命的第一年体重不足风险显著更高，且发病情况也显著更严重。
