甲基氯化汞和双（甲基汞）硒对豚鼠离体肠平滑肌反应的影响。

Effects of methylmercuric chloride and bis (methylmercuric) selenide on responses of isolated intestinal smooth muscle of the guinea-pig.

作者信息

Fukushi Y, Yamamoto R

出版信息

Tohoku J Exp Med. 1985 Mar;145(3):243-9. doi: 10.1620/tjem.145.243.

DOI:10.1620/tjem.145.243

Abstract

The neurologically toxic substance, methylmercury, is detoxified by simultaneous application of selenite. In vivo formation of bis (methylmercuric) selenide has been suggested as the mechanism of detoxication by selenite. By using isolated guinea-pig taenia coli preparations, the effects of methylmercuric chloride and bis (methylmercuric) selenide on contractile responses to nerve and direct stimulation were investigated. Application of either drugs scarcely affected contractile responses to direct stimulation. However, contractile responses to nerve stimulation were severely reduced by methylmercuric chloride. The effect of bis (methylmercuric) selenide was considerably weaker than methylmercuric chloride. The site blocked by methylmercuric chloride and bis (methylmercuric) selenide in the taenia preparation was discussed.

摘要

具有神经毒性的物质甲基汞可通过同时施用亚硒酸盐来解毒。有人提出，亚硒酸盐解毒的机制是在体内形成双（甲基汞）硒化物。利用离体豚鼠结肠带制备物，研究了氯化甲基汞和双（甲基汞）硒化物对神经和直接刺激引起的收缩反应的影响。施用这两种药物几乎都不影响对直接刺激的收缩反应。然而，氯化甲基汞严重降低了对神经刺激的收缩反应。双（甲基汞）硒化物的作用比氯化甲基汞弱得多。讨论了氯化甲基汞和双（甲基汞）硒化物在结肠带制备物中所阻断的部位。