甲基汞和亚硒酸盐处理的大鼠中双（甲基汞）硒化物的形成及其可能作用

Formation and possible role of bis(methylmercuric) selenide in rats treated with methylmercury and selenite.

作者信息

Masukawa T, Kito H, Hayashi M, Iwata H

出版信息

Biochem Pharmacol. 1982 Jan 1;31(1):75-8. doi: 10.1016/0006-2952(82)90239-8.

Abstract

The metabolic fate of methylmercury after administration of [203Hg]-methylmercuric chloride in combination with sodium selenite was investigated in rats. Whole body autoradiography and radioassay showed that administration of selenite decreased the mercury concentration in the liver and kidney, and increased that in the brain. The rapid changes of methylmercury concentration in the tissues after selenite injection were accompanied by increase in mercury extractable with benzene at neutral pH. The maximum levels of benzene-extractable mercury in the blood, kidney and liver were attained 30 min after selenite injection and were 30, 23 and 8 percent, respectively, of the total mercury. Thin-layer chromatography showed that the benzene-extractable mercury was a complex of methylmercury with selenium, bis(methylmercuric) selenide. These findings indicate that selenite alters the distribution of methylmercury in the tissues by formation of a diffusible complex with methylmercury, bis(methylmercuric) selenide.

摘要

在大鼠中研究了给予[203Hg] - 甲基氯化汞并结合亚硒酸钠后甲基汞的代谢命运。全身放射自显影和放射性测定表明，给予亚硒酸盐可降低肝脏和肾脏中的汞浓度，并增加大脑中的汞浓度。注射亚硒酸盐后组织中甲基汞浓度的快速变化伴随着中性pH下可被苯提取的汞的增加。注射亚硒酸盐后30分钟，血液、肾脏和肝脏中苯可提取汞的最高水平分别达到总汞的30%、23%和8%。薄层色谱显示，苯可提取汞是甲基汞与硒的复合物，即双（甲基汞）硒化物。这些发现表明，亚硒酸盐通过与甲基汞形成可扩散的复合物双（甲基汞）硒化物来改变甲基汞在组织中的分布。