Oshima Y
Tohoku J Exp Med. 1985 Mar;145(3):329-33. doi: 10.1620/tjem.145.329.
Changes in insulin secretory responses by diet restriction were analyzed in non-insulin-dependent non-obese diabetic subjects (NIDDM-NO) as well as in healthy volunteers by determining 24-hr urinary C-peptide immunoreactivity (24-hr UCPR). Insulin sensitivity for glucose utilization was measured by using cyclic somatostatin. Overnight fasting plasma glucose concentrations decreased in NIDDM-NO; however, 24-hr UCPR was reduced in both NIDDM-NO and healthy controls by diet restriction (25 kcal/kg) for 14 days. The level of 24-hr UCPR was higher but insulin sensitivity was lower in NIDDM-NO as compared with those in healthy controls. Therefore, diet restriction may be effective in controlling hyperglycemia and hypersecretion of insulin in NIDDM-NO, but it alone may not improve the reduced insulin sensitivity.
通过测定24小时尿C肽免疫反应性（24小时UCPR），分析了饮食限制对非胰岛素依赖型非肥胖糖尿病患者（NIDDM-NO）以及健康志愿者胰岛素分泌反应的影响。使用环孢素测定胰岛素对葡萄糖利用的敏感性。NIDDM-NO患者过夜空腹血糖浓度降低；然而，通过14天的饮食限制（25千卡/千克），NIDDM-NO患者和健康对照者的24小时UCPR均降低。与健康对照者相比，NIDDM-NO患者的24小时UCPR水平较高，但胰岛素敏感性较低。因此，饮食限制可能对控制NIDDM-NO患者的高血糖和胰岛素分泌过多有效，但单独使用可能无法改善降低的胰岛素敏感性。
