Raevskiĭ K S, Aleksandrovskiĭ Iu A, Poiurovskiĭ M V, Kharlamov A N, Neznamov G G
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(4):574-9.
An experimental and clinico-pharmacological study of sodium valproate, a GABA-ergic drug, was conducted to elucidate the role of gamma-aminobutyric acid in the mechanisms responsible for affective disturbances, in particular for anxiety. A tranquilizing effect of the drug, comparable with the action of diazepam, was established in a conflict situation model in experimental animals. Using clinico-psychological methods the authors showed a distinct tranquilizing action of valproate in patients suffering from neurotic and neurosis-like disorders with manifestations of anxiety in the structure of the psychopathological syndrome. It was established that this action was accompanied by no manifestations of myorelexation, ataxia or somnolence characteristic of tranquilizers of the benzodiazepine series. The presence of tranquilizing properties in the GABA-ergic drug sodium valproate confirms the suggestion that a certain relationship exists between the GABA system and anxiety.
对γ-氨基丁酸能药物丙戊酸钠进行了一项实验和临床药理学研究，以阐明γ-氨基丁酸在情感障碍，特别是焦虑症发病机制中的作用。在实验动物的冲突情境模型中确定了该药物的镇静作用，其与地西泮的作用相当。作者采用临床心理学方法表明，丙戊酸钠对患有神经症和类神经症性障碍且心理病理综合征结构中有焦虑表现的患者具有明显的镇静作用。已确定这种作用并未伴有苯二氮䓬类镇静剂特有的肌松弛、共济失调或嗜睡表现。γ-氨基丁酸能药物丙戊酸钠具有镇静特性，这证实了γ-氨基丁酸系统与焦虑之间存在某种关系的推测。
