Aleksandrovskiĭ Iu A, Ben'kovich B I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(5):743-50.
A comparative clinical and pharmacological analysis of the neurovegetotropic activity of the tranquilizers phenazepam and diazepam (benzodiazepine derivatives) was carried out in 287 patients with neurotic disturbances. The patients were analyzed for the genesis, structure and nature of vegetative-effector permanent and paroxysmal disorders. The regular characteristics of the interrelationship between the major psychopathological syndrome and the nature of vasovegetative dysfunctions were established. Considering the above, the differential method was used to study the therapeutic time-course of the status of patients treated with the tranquilizers. Phenazepam was shown to have a predominantly sympatheticotropic action. Comparative analysis of the therapeutic response points to a higher effectiveness of phenazepam in cases of the paroxysmal and of diazepam in cases of the permanent nature of vegetative dysfunctions.
对287例神经症患者进行了镇静剂非那西泮和地西泮（苯二氮䓬衍生物）的拟神经亲和活性的临床与药理学对比分析。分析了患者植物性效应器持续性和阵发性障碍的成因、结构及性质。确立了主要精神病理综合征与血管植物神经功能障碍性质之间相互关系的规律特征。基于上述情况，采用差异法研究了使用镇静剂治疗的患者病情的治疗时间进程。结果表明，非那西泮主要具有拟交感神经作用。治疗反应的对比分析表明，在植物神经功能障碍呈阵发性时，非那西泮疗效更高；而在呈持续性时，地西泮疗效更高。
