Rojas Juan Ignacio, Patrucco Liliana, Trojano Maria, Lugaresi Alessandra, Izquierdo Guillermo, Butzkueven Helmut, Jokubaitis Vilija, Duquette Pierre, Girard Marc, Grand'Maison Francois, Grammond Pierre, Oreja-Guevara Celia, Hupperts Raymond, Boz Cavit, Petersen Thor, Bergamaschi Roberto, Giuliani Giorgio, Lechner-Scott Jeannette, Barnett Michael, Rio Maria Edite, Van Pesch Vincent, Amato Maria Pia, Iuliano Gerardo, Fiol Marcela, Slee Mark, Verheul Freek, Fernandez-Bolanos Ricardo, Poehlau Dieter, Saladino Maria Laura, Braber-Moerland Leontien Den, Deri Norma, Oleschko-Arruda Walter, Cabrera-Gomez Jose Antonio, Paine Mark, Vella Norbert, Kister Ilya, Skromne Eli, Savino Aldo, Shaw Cameron, Moore Fraser, Vucic Steve, Petkovska-Boskova Tatjana, Bacile Elizabeth Alejandra Bacile, Santiago Vetere, Cristiano Edgardo
Multiple Sclerosis Center, Hospital Italiano, Argentina.
Department of Basic Medical Sciences, Neuroscience, and Sense Organs, University of Bari, Italy.
Mult Scler J Exp Transl Clin. 2015 Aug 17;1:2055217315600193. doi: 10.1177/2055217315600193. eCollection 2015 Jan-Dec.
Limited data suggest that multiple sclerosis (MS) in Latin America (LA) could be less severe than in the rest of the world. The objective was to compare the course of MS between LA and other regions.
Centers from 18 countries with >20 cases enrolled in the MSBase Registry participated. Patients with MS with a disease duration of >1 year and <30 years at time of EDSS measurement were evaluated. The MS Severity Score (MSSS) was used as a measure of disease progression. Comparisons among regions (North America, Europe, Australia and LA), hemispheres and countries were performed.
A total of 9610 patients were included. Patients were from: Europe, 6290 (65.6%); North America, 1609 (16.7%); Australia, 1119 (11.6%); and LA, 592 (6.1%). The mean MSSS in patients from LA was 4.47 ± 2.8, 4.53 ± 2.8 in North America, 4.51 ± 2.8 in Europe and 4.49 ± 2.7 in Australia. Mean MSSS in the northern hemisphere was 4.51 ± 1.6 compared to 4.48 ± 1.9 in the southern hemisphere. No differences were found for MSSS among hemispheres ( = 0.68), regions ( = 0.96) or countries ( = 0.50).
Our analyses did not discover any difference in mean MSSS among patients from different regions, hemispheres or countries.
有限的数据表明，拉丁美洲（LA）的多发性硬化症（MS）可能不如世界其他地区严重。目的是比较LA与其他地区MS的病程。
来自18个国家的中心参与了MSBase注册研究，每个中心登记的病例超过20例。对疾病持续时间超过1年且在进行扩展残疾状态量表（EDSS）测量时病程小于30年的MS患者进行评估。使用MS严重程度评分（MSSS）作为疾病进展的衡量指标。对各地区（北美、欧洲、澳大利亚和LA）、半球和国家进行了比较。
共纳入9610例患者。患者来自：欧洲，6290例（65.6%）；北美，1609例（16.7%）；澳大利亚，1119例（11.6%）；LA，592例（6.1%）。LA患者的平均MSSS为4.47±2.8，北美为4.53±2.8，欧洲为4.51±2.8，澳大利亚为4.49±2.7。北半球的平均MSSS为4.51±1.6，南半球为4.48±1.9。半球（P = 0.68）、地区（P = 0.96）或国家（P = 0.50）之间的MSSS无差异。
我们的分析未发现不同地区、半球或国家患者的平均MSSS存在差异。
