Patel Kevin R, Luo Jie, Alvarez Enrique, Piccio Laura, Schmidt Robert E, Yablonskiy Dmitriy A, Cross Anne H
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, USA.
Research Laboratory of Electronics, Massachusetts Institute of Technology, USA.
Mult Scler J Exp Transl Clin. 2015 Sep 24;1:2055217315606465. doi: 10.1177/2055217315606465. eCollection 2015 Jan-Dec.
Cortical lesions occur early in multiple sclerosis (MS) and are thought to have clinical implications. Conventional MRI is insensitive to cortical pathology. Investigational imaging modalities show improved but incomplete cortical lesion detection and are time and resource intensive. Gradient echo plural contrast imaging (GEPCI) is sensitive to MS white matter pathology and can be performed on standard MRI scanners. Here we used GEPCI to examine autopsied MS frontal brain tissues. Two cortical MS lesions were visually distinguished from surrounding tissue by GEPCI and immunohistochemical staining. Furthermore, these lesions were quantitatively differentiated from healthy tissue using GEPCI-derived metrics.
皮质病变在多发性硬化症（MS）早期出现，被认为具有临床意义。传统MRI对皮质病理改变不敏感。研究性成像方式在皮质病变检测方面有所改善，但仍不完整，且耗费时间和资源。梯度回波多对比成像（GEPCI）对MS白质病变敏感，可在标准MRI扫描仪上进行。在此，我们使用GEPCI检查经尸检的MS额叶脑组织。通过GEPCI和免疫组织化学染色在视觉上可将两个皮质MS病变与周围组织区分开来。此外，使用GEPCI衍生指标可将这些病变与健康组织进行定量区分。
