Patel Viral P, Zambrana Aaron, Walker Lisa As, Herrmann Nathan, Swartz Richard H, Feinstein Anthony
Department of Psychiatry, Sunnybrook Health Sciences Centre, Canada.
Ottawa Hospital Research Institute, Canada.
Mult Scler J Exp Transl Clin. 2016 Jun 7;2:2055217316653150. doi: 10.1177/2055217316653150. eCollection 2016 Jan-Dec.
The present study assesses the influence of depression and anxiety on the effects of cognitive distracters in people with multiple sclerosis (MS). Participants completed computerized versions of the Symbol Digit Modalities Test (c-SDMT) with ( = 51) and without ( = 51) auditory distracters. Based on the Hospital Anxiety and Depression Scale (HADS), 29 (28.4%) and 51 (50%) participants were classified as depressed or anxious, respectively. A regression analysis revealed that depression ( = 0.034), not anxiety ( = 0.264), further impaired performance on the c-SDMT, particularly in the presence of distracters. These results suggest that distracter effects are influenced by depression more than anxiety. Given that distracters are ubiquitous in real-world environments, their use in a cognitive assessment adds to the ecological validity of the results.
本研究评估了抑郁和焦虑对多发性硬化症（MS）患者认知干扰因素效果的影响。参与者完成了有（n = 51）和无（n = 51）听觉干扰因素的计算机化符号数字模态测试（c-SDMT）。根据医院焦虑抑郁量表（HADS），分别有29名（28.4%）和51名（50%）参与者被归类为抑郁或焦虑。回归分析显示，是抑郁（β = 0.034）而非焦虑（β = 0.264）进一步损害了c-SDMT的表现，尤其是在存在干扰因素的情况下。这些结果表明，干扰因素的效果受抑郁的影响大于焦虑。鉴于干扰因素在现实环境中无处不在，在认知评估中使用它们增加了结果的生态效度。
