Cuello-López Javier, Fidalgo-Zapata Ana, Vásquez-Trespalacios Elsa
Clinical Oncology Group, Fundación Colombiana de Cancerología-Clínica Vida, Medellín, Colombia.
Breast Surgeon Fellowship Program, School of Medicine, CES University, Medellín, Colombia.
Int J Breast Cancer. 2017;2017:9574874. doi: 10.1155/2017/9574874. Epub 2017 May 18.
Obesity is an established risk factor for cancer and cancer-related deaths, including that of the breast. While the prevalence of female obesity has accelerated over the past decade in many developing countries, such as Colombia, the prevalence of overweight and obesity specifically in breast cancer populations has not been fully described.
A cross-sectional study including 849 women diagnosed with breast cancer between 2009 and 2014. Based on body mass index, prevalence of overweight (BMI ≥ 25 < 30) and obesity (BMI ≥ 30) and associations of BMI with clinical and tumor histopathological features were analyzed.
Colombian breast cancer patients had a prevalence of overweight of 34.28% and obesity of 28.15%. Mean BMI was comparable between premenopausal and postmenopausal women (27.2 versus 27.7, resp.). Among premenopausal women, higher BMI was significantly positively associated with hormone receptor negative tumors, as well as with greater lymphovascular invasion.
Colombian breast cancer patients exhibit a significant prevalence of overweight and obesity. Associations of high BMI and poor prognosis variables in the premenopausal population suggest risk of aggressive disease in this population. Future studies to further validate our observations are warranted in order to implement multidisciplinary clinical guidelines.
肥胖是癌症及癌症相关死亡的既定风险因素，包括乳腺癌。在许多发展中国家，如哥伦比亚，过去十年女性肥胖患病率加速上升，但超重和肥胖在乳腺癌人群中的患病率尚未得到充分描述。
一项横断面研究纳入了2009年至2014年间确诊为乳腺癌的849名女性。根据体重指数，分析超重（体重指数≥25<30）和肥胖（体重指数≥30）的患病率以及体重指数与临床和肿瘤组织病理学特征的关联。
哥伦比亚乳腺癌患者超重患病率为34.28%，肥胖患病率为28.15%。绝经前和绝经后女性的平均体重指数相当（分别为27.2和27.7）。在绝经前女性中，较高的体重指数与激素受体阴性肿瘤以及更大的淋巴管浸润显著正相关。
哥伦比亚乳腺癌患者中超重和肥胖的患病率较高。绝经前人群中高体重指数与预后不良变量之间的关联表明该人群存在侵袭性疾病风险。有必要开展进一步研究以验证我们的观察结果，从而实施多学科临床指南。
